The Epidemiology of Pregnancy-Related Breast Cancers: Are We Ready to Deliver?
The Epidemiology of Pregnancy-Related Breast Cancers: Are We Ready to Deliver?
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妊娠相关乳腺癌的流行病学：我们准备好分娩了吗？
DOI：
10.1158/1055-9965.epi-21-1445
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发表时间：
2022
期刊：
影响因子：
--
通讯作者：
Terry,MaryBeth
中科院分区：
文献类型：
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作者：
McDonald,JasmineA;Vilfranc,ChrystelleL;Terry,MaryBeth
怀孕对乳腺癌风险的双重影响早已被认识到。怀孕后乳腺癌的短期增加，特别是更具侵袭性的癌症，与长期减少形成鲜明对比。目前尚不清楚怀孕的这些相反影响与乳腺癌的分子亚型之间的关系，这会影响翻译。一些方法学上的挑战仍然与关键结构的研究和操作有关，这些结构仍然由于怀孕年龄、总体产次以及怀孕和癌症诊断之间的间隔之间的相关性而变得复杂。在本期CEBP中，Vohra及其同事解决了这些主要差距中的一些，并提供了有关乳腺组织微环境的新数据。50岁以下女性浸润性乳腺癌发病率的增加需要改善临床翻译和识别妊娠后的高风险女性。因此，解决我们对妊娠相关乳腺癌的生物学理解方面的差距至关重要。第561页
The dual effect of pregnancy on breast cancer risk has long been recognized. The short-term increase in breast cancer after pregnancy, particularly cancers that are more aggressive, contrasts starkly with the longer-term decrease. It remains unclear how these opposing effects of pregnancy relate to molecular subtypes of breast cancer, which impacts translation. Several methodologic challenges remain related to the study and operationalization of key constructs, which remain complicated by the correlation between age at pregnancies, overall parity, and intervals between pregnancies and cancer diagnoses. In this issue ofCEBP, Vohra and colleagues address some of these major gaps as well as present novel data on the breast tissue microenvironment. The increasing incidence of invasive breast cancer in women under age 50 years requires improved clinical translation and identification of higher risk women after pregnancy. Thus, it is crucial to address the gaps in our biological understanding of pregnancy-related breast cancers.See related article by Vohra et al., p. 561