Parental Education Predicts Corticostriatal Functionality in Adulthood
Parental Education Predicts Corticostriatal Functionality in Adulthood
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DOI：
10.1093/cercor/bhq160
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发表时间：
2011-04-01
期刊：
影响因子：
3.7
通讯作者：
Hariri, Ahmad R.
中科院分区：
文献类型：
--
作者：
Gianaros, Peter J.;Manuck, Stephen B.;Hariri, Ahmad R.
在早期发展中所经历的社会经济劣势预示着成年后的健康状况不佳。然而，将早期不利因素与成人健康联系起来的神经生物学途径仍不清楚。较低的父母教育-早期社会经济障碍的一个假定指标-预测健康损害的成年行为，包括烟草和酒精依赖。这些行为部分取决于皮质纹状体脑系统的功能，这些功能1）显示发育可塑性和早期脆弱性，2）处理与奖励相关的信息，3）调节冲动的决定和行动。因此，成年期皮质纹状体功能可能直接与早期社会经济劣势指标相关，特别是父母教育程度较低。在这里，我们测试了76名没有混淆临床综合征的成年人的父母教育和皮质纹状体激活和连接之间的协变。皮质纹状体的激活和连通性进行了评估，在处理的刺激信号货币收益（正反馈[PF]）和损失（负反馈）。在考虑了参与者自身的教育程度和其他解释因素后，父母教育程度较低预示着PF期间前扣带和背内侧前额叶皮质的激活减少，沿着这些皮质与涉及奖励处理和冲动调节的眶额和纹状体区域之间的连接减少。在推测中，成人皮质纹状体功能的改变可能代表与早期发育的社会经济条件相关的神经生物学内表型的方面。
Socioeconomic disadvantage experienced in early development predicts ill health in adulthood. However, the neurobiological pathways linking early disadvantage to adult health remain unclear. Lower parental education-a presumptive indicator of early socioeconomic disadvantage-predicts health-impairing adult behaviors, including tobacco and alcohol dependencies. These behaviors depend, in part, on the functionality of corticostriatal brain systems that 1) show developmental plasticity and early vulnerability, 2) process reward-related information, and 3) regulate impulsive decisions and actions. Hence, corticostriatal functionality in adulthood may covary directly with indicators of early socioeconomic disadvantage, particularly lower parental education. Here, we tested the covariation between parental education and corticostriatal activation and connectivity in 76 adults without confounding clinical syndromes. Corticostriatal activation and connectivity were assessed during the processing of stimuli signaling monetary gains (positive feedback [PF]) and losses (negative feedback). After accounting for participants' own education and other explanatory factors, lower parental education predicted reduced activation in anterior cingulate and dorsomedial prefrontal cortices during PF, along with reduced connectivity between these cortices and orbitofrontal and striatal areas implicated in reward processing and impulse regulation. In speculation, adult alterations in corticostriatal functionality may represent facets of a neurobiological endophenotype linked to socioeconomic conditions of early development.