Cortisol-induced impairments of working memory require acute sympathetic activation
Cortisol-induced impairments of working memory require acute sympathetic activation
复制标题
DOI：
10.1037/0735-7044.119.1.98
复制
发表时间：
2005-02-01
影响因子：
1.9
通讯作者：
Roelofs, K
中科院分区：
文献类型：
--
作者：
Elzinga, BM;Roelofs, K
目前的研究评估了皮质醇对工作记忆的影响是否取决于记忆表现中肾上腺素能活动的水平（通过交感神经激活来测量）。在暴露于社会心理压力任务后，参与者被分为皮质醇反应者和无反应者。皮质醇反应者在社会心理应激阶段表现出工作记忆障碍，此时皮质醇和肾上腺素能活性增强，而无反应者则没有。然而，在恢复期间，当皮质醇水平升高但肾上腺素能活动正常化时，反应者的工作记忆与无反应者的工作记忆没有差异。在几种压力测量中，皮质醇是压力下工作记忆表现的唯一显著预测因子。这些发现表明，肾上腺素能激活对于应激诱导的皮质醇对工作记忆的损害作用是必不可少的。
The present study assessed whether the effects of cortisol on working memory depend on the level of adrenergic activity (as measured by sympathetic activation) during memory performance. After exposure to a psychosocial stress task, participants were divided into cortisol responders and nonresponders. Cortisol responders showed working memory impairments during the psychosocial stress phase, when cortisol and adrenergic activity were enhanced, whereas nonresponders did not. During recovery, however, when cortisol levels were elevated but adrenergic activity was normalized, working memory of responders did not differ from that of nonresponders. Among several stress measures, cortisol was the only significant predictor for working memory performance during stress. These findings suggest that adrenergic activation is essential for the impairing effects of stress-induced cortisol on working memory.