The long noncoding RNA lncPARP1 contributes to progression of hepatocellular carcinoma through up-regulation of PARP1
The long noncoding RNA lncPARP1 contributes to progression of hepatocellular carcinoma through up-regulation of PARP1
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长非编码RNA lncPARP1通过上调PARP1促进肝细胞癌的进展
DOI：
10.1042/bsr20180703
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发表时间：
2018
影响因子：
4
通讯作者：
Yin Zhenyu
中科院分区：
文献类型：
--
作者：
Qi Heqiang;Lu Yuyan;Lv Jie;Wu Huita;Lu Jing;Zhang Changmao;Zhang Sheng;Bao Qing;Zhang Xiuming;Xie Chengrong;Yin Zhenyu
肝细胞癌（HCC）占全球癌症相关死亡率的很大比例。长链非编码RNA（lncRNA）在人类癌症中的功能影响尚未完全了解。在这里，我们发现了一种新的致癌lncRNA，称为lncPARP 1，这是显着上调肝癌。lncPARP 1表达增加与HCC患者的年龄、甲胎蛋白（AFP）水平、肿瘤大小、复发和预后不良相关。功能丧失的方法表明，敲低lncPARP 1抑制肝癌细胞的增殖，迁移和侵袭，同时诱导凋亡。此外，机制研究表明，PARP 1是HCC中lncPARP 1的潜在靶点。总之，我们提供了第一个证据，lncPARP 1发挥癌基因，以促进肝癌的发展和进展，至少部分，通过影响聚（ADP-核糖）（PAR）聚合酶1（PARP 1）的表达。
Hepatocellular carcinoma (HCC) accounts for a large proportion of cancer-associated mortality worldwide. The functional impact of long noncoding RNAs (lncRNAs) in human cancer is not fully understood. Here, we identified a novel oncogenic lncRNA termed as lncPARP1, which was significantly up-regulated in HCC. Increase in lncPARP1 expression was associated with age, α-fetoprotein (AFP) levels, tumor size, recurrence, and poor prognosis of HCC patients. Loss-of-function approaches showed that knockdown of lncPARP1 inhibited proliferation, migration, and invasion, while induced apoptosis in HCC cells. Moreover, mechanistic investigation demonstrated that PARP1 was an underlying target of lncPARP1 in HCC. In summary, we provide the first evidence that lncPARP1 exerts an oncogene to promote HCC development and progression, at least in part, by affecting poly (ADP-ribose) (PAR) polymerase 1 (PARP1) expression.