Cardiorespiratory fitness in young adulthood and the development of cardiovascular disease risk factors
Cardiorespiratory fitness in young adulthood and the development of cardiovascular disease risk factors
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DOI：
10.1001/jama.290.23.3092
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发表时间：
2003-12-17
影响因子：
120.7
通讯作者：
Liu, K
中科院分区：
文献类型：
--
作者：
Carnethon, MR;Gidding, SS;Liu, K
低心肺适应性是心血管疾病和总死亡率的一个确定的危险因素;目的探讨通过短时间最大负荷平板运动试验评估的低体能是否能预测心血管疾病危险因素的发展，以及改善体能是否能预测心血管疾病危险因素的发展。（两次检查之间活动平板试验持续时间增加）与风险降低相关。设计，设置，在年轻人冠状动脉风险发展（CARDIA）研究中，对18至30岁的男性和女性进行了基于人群的纵向队列研究。在基线时根据Balke方案完成跑步机检查的参与者从1985-1986年到2000-2001年进行随访。1992- 1993年，一组参与者（n=2478）重复了运动试验。主要结果测量2型糖尿病、高血压、代谢综合征的发病率（根据国家胆固醇教育计划成人治疗小组111定义），和高胆固醇血症（低密度脂蛋白胆固醇大于或等于160 mg/dL [4.14 mmol/L]）。结果在15年的研究期间，糖尿病、高血压、代谢综合征和高胆固醇血症分别为2.8、13.0、10.2和11.7/1000人-年。在对年龄、种族、性别、吸烟和糖尿病、高血压或早发心肌梗死家族史进行校正后，低体能（= 60百分位）的参与者，所有P
Context Low cardiorespiratory fitness is an established risk factor for cardiovascular and total mortality; however, mechanisms responsible for these associations are uncertain.Objective To test whether low fitness, estimated by short duration on a maximal treadmill test, predicted the development of cardiovascular disease risk factors and whether improving fitness (increase in treadmill test duration between examinations) was associated with risk reduction.Design, Setting, and Participants Population-based longitudinal cohort study of men and women 18 to 30 years of age in the Coronary Artery Risk Development in Young Adults (CARDIA) study. Participants who completed the treadmill examination according to the Balke protocol at baseline were followed up from 1985-1986 to 2000-2001. A subset of participants (n=2478) repeated the exercise test in 1992-1993.Main Outcome Measures Incident type 2 diabetes, hypertension, the metabolic syndrome (defined according to National Cholesterol Education Program Adult-Treatment Panel 111), and hypercholesterolemia (low-density lipoprotein cholesterol greater than or equal to160 mg/dL [4.14 mmol/L]).Results During the 15-year study period, the rates of incident diabetes, hypertension, the metabolic syndrome, and hypercholesterolemia were 2.8, 13.0, 10.2, and 11.7 per 1000 person-years, respectively. After adjustment for age, race, sex, smoking, and family history of diabetes, hypertension, or premature myocardial infarction, participants with low fitness (= 60th percentile), all P