Growth-dependent change of the 26S proteasome in budding yeast
Growth-dependent change of the 26S proteasome in budding yeast
复制标题
DOI：
10.1006/bbrc.1998.9560
复制
发表时间：
1998-10-29
影响因子：
3.1
通讯作者：
Yokosawa, H
中科院分区：
文献类型：
--
作者：
Fujimuro, M;Takada, H;Yokosawa, H
26S蛋白酶体由20S蛋白酶体和调节亚基复合物以ATP依赖性方式组装而成。在本研究中，我们发现，在芽殖酵母酿酒酵母的生长过程中，26 S蛋白酶体的ATP依赖的活性和蛋白量的变化。稳定期的20S蛋白酶体水平均高于指数生长期的20S蛋白酶体水平，而20S蛋白酶体水平在生长过程中似乎保持不变。这些结果表明，26 S蛋白酶体经历了生长依赖性的变化，26 S蛋白酶体在饥饿条件下酵母细胞的生存中发挥作用。(C)北京：科学出版社.
The 26S proteasome is assembled from the 20S proteasome and the regulatory subunit complex in an ATP-dependent manner. In the present study, we found that the ATP-dependent activity and the protein amount of the 26S proteasome change during growth of the budding yeast Saccharomyces cerevisiae. Both levels in the stationary phase are higher than those in the exponentially growing phase, On the other hand, the levels of the 20S proteasome appear to remain unchanged during growth. These results suggest that the 26S proteasome undergoes a growth-dependent change and that the 26S proteasome plays a role in the survival of yeast cells under starvation conditions. (C) 1998 Academic Press.