The effect of elevated progesterone levels before oocyte retrieval in women undergoing ovarian stimulation for IVF treatment on the genomic profile of peri-implantation endometrium
The effect of elevated progesterone levels before oocyte retrieval in women undergoing ovarian stimulation for IVF treatment on the genomic profile of peri-implantation endometrium
复制标题
接受卵巢刺激体外受精治疗的女性在取卵前黄体酮水平升高对围着床期子宫内膜基因组谱的影响
DOI：
10.1016/j.jri.2017.05.001
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发表时间：
2017-06-01
影响因子：
3.4
通讯作者：
Zhang, Songying
中科院分区：
文献类型：
--
作者：
Liu, Liu;Huang, Jin;Zhang, Songying
为了评价取卵前高孕酮对围着床期子宫内膜基因组谱的影响，我们进行了这项单中心、前瞻性队列研究。根据hCG给药当天和hCG给药后当天的孕酮水平是否升高，包括总共20名接受IVF治疗的未进行新鲜胚胎移植的妇女：组1是指两天孕酮水平正常的受试者;第2组是指hCG给药当天孕酮水平正常，hCG给药后当天孕酮水平高的受试者;第3组是指hCG给药当天孕酮水平较高，hCG给药后第二天孕酮水平正常的受试者;第4组是指两天孕酮水平均较高的受试者。每组包括5名受试者。在hCG给药后7天获得子宫内膜样品。我们发现，高孕酮水平取卵前主要影响NK细胞介导的细胞毒性途径在子宫内膜的组成部分，显着差异，只有当孕酮测量的一天和一天后，hCG管理被认为是在一起。
To evaluate the effects of high progesterone prior to oocyte retrieval on the genomic profile of peri-implantation endometrium, we conducted this single-center, prospective cohort study. Depending on whether or not the progesterone level on the day of hCG administration and the day after hCG administration were elevated, a total of 20 women undergoing IVF treatment who did not have fresh embryo transfer were included: Group 1 refers to subjects with normal progesterone level on both days; Group 2 refers to subjects with normal progesterone level on the day of hCG administration and high progesterone level on the day after hCG administration; Group 3 refers to subjects with high progesterone level on the day of hCG administration and normal progesterone level on the day after hCG administration; Group 4 refers to subjects with high progesterone level on both days. Five subjects were included in each group. Endometrial samples were obtained 7 days after hCG administration. We found that high progesterone level prior to oocyte retrieval predominantly affected components of the NK cell mediated cytotoxicity pathway in the endometrium and that significant differences were only seen when progesterone measurements on both the day of and day after hCG administration were considered together.