Defining a robe for fibroblasts in the persistence of chronic inflammatory joint disease
Defining a robe for fibroblasts in the persistence of chronic inflammatory joint disease
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DOI：
10.1136/ard.2004.028332
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发表时间：
2004-11-01
影响因子：
27.4
通讯作者：
Salmon, M
中科院分区：
文献类型：
--
作者：
Buckley, CD;Filer, A;Salmon, M
类风湿性关节炎的炎症反应最令人惊讶的特征不是它发生，而是它不消退。慢性炎症反应的持续性伴随着持续的关节破坏是许多类风湿性关节炎患者非常熟悉的发现。尽管使用了有效的抗炎剂和疾病修饰药物，但仍有相当比例的类风湿性关节炎患者继续患有耐药性疾病。完全临床缓解超过六个月是不寻常的，这种疾病的正式治愈仍然难以捉摸。在这份报告中，我们专注于如何试图解决为什么类风湿性关节炎持续存在的问题，导致了不同的解释类风湿性疾病的发病机制，其中基质细胞，如成纤维细胞的改变发挥了重要作用，从解决到持续性疾病的开关。
The most surprising feature of the inflammatory response in rheumatoid arthritis is not that it occurs but that it does not resolve. The persistence of the chronic inflammatory response in conjunction with ongoing joint destruction is an all too familiar finding in many patients with rheumatoid arthritis. Despite the use of effective anti-inflammatory agents and disease modifying drugs, a significant proportion of patients with rheumatoid arthritis continue to have resistant disease. Complete clinical remission is unusual for more than six months and a formal cure of the disease remains elusive. In this report we focus on how attempts to address the question of why rheumatoid arthritis persists have led to a different interpretation of the pathogenesis of rheumatoid disease; one in which alterations in stromal cells such as fibroblasts play an important role in the switch from resolving to persistent disease.