Toward Bacterial Bioelectric Signal Transduction
Toward Bacterial Bioelectric Signal Transduction
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DOI：
10.1089/bioe.2021.0013
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发表时间：
2021-06-01
期刊：
影响因子：
2.3
通讯作者：
Larkin, Joseph W.
中科院分区：
文献类型：
--
作者：
Jones, Joshua M.;Larkin, Joseph W.
细菌是带电的有机体；细胞在其质膜上保持电势，作为驱动基本过程的自由能量的来源。然而，近些年来，细菌的膜电位已经越来越被认为是动态的。这些动力学与多种生理功能和行为有关，包括细胞分裂和细胞间信号传递。在真核细胞中，这种动力学在生物电刺激与内部细胞状态变化的耦合中发挥着重要作用。神经学家和生理学家已经建立了详细的分子通路，将真核膜电位动态转化为生理和基因表达反应。我们才刚刚开始探索细菌对生物电活动的这些细胞内反应。在这篇综述中，我们总结了这一领域的进展，包括基因表达对电极刺激的反应和机械诱导的膜电位尖峰。我们认为，挑衅性的结果、缺失的分子细节和新兴的工具相结合，使生物电诱导的长期细胞内反应的研究成为微生物学未来的一项重要而有回报的努力。
Bacteria are electrically powered organisms; cells maintain an electrical potential across their plasma membrane as a source of free energy to drive essential processes. In recent years, however, bacterial membrane potential has been increasingly recognized as dynamic. Those dynamics have been implicated in diverse physiological functions and behaviors, including cell division and cell-to-cell signaling. In eukaryotic cells, such dynamics play major roles in coupling bioelectrical stimuli to changes in internal cell states. Neuroscientists and physiologists have established detailed molecular pathways that transduce eukaryotic membrane potential dynamics to physiological and gene expression responses. We are only just beginning to explore these intracellular responses to bioelectrical activity in bacteria. In this review, we summarize progress in this area, including evidence of gene expression responses to stimuli from electrodes and mechanically induced membrane potential spikes. We argue that the combination of provocative results, missing molecular detail, and emerging tools makes the investigation of bioelectrically induced long-term intracellular responses an important and rewarding effort in the future of microbiology.