Reusable Nickel Nanoparticles-Catalyzed Reductive Amination for Selective Synthesis of Primary Amines
Reusable Nickel Nanoparticles-Catalyzed Reductive Amination for Selective Synthesis of Primary Amines
复制标题
DOI：
10.1002/anie.201812100
复制
发表时间：
2019-04-01
影响因子：
16.6
通讯作者：
Jagadeesh, Rajenahally, V
中科院分区：
文献类型：
--
作者：
Murugesan, Kathiravan;Beller, Matthias;Jagadeesh, Rajenahally, V
介绍了通过在二氧化硅上原位生成的镍酒石酸络合物的热解制备镍纳米粒子作为有效的还原胺化催化剂。由此产生的稳定且可重复使用的镍纳米催化剂使得能够在分子氢存在下从廉价且容易获得的羰基化合物和氨开始合成官能化且结构多样的伯苄胺、杂环胺和脂肪胺。应用这种基于镍的胺化方案，可以将-NH2部分引入结构复杂的化合物中，例如类固醇衍生物和药物。
The preparation of nickel nanoparticles as efficient reductive amination catalysts by pyrolysis of in situ generated Ni-tartaric acid complex on silica is presented. The resulting stable and reusable Ni-nanocatalyst enables the synthesis of functionalized and structurally diverse primary benzylic, heterocyclic and aliphatic amines starting from inexpensive and readily available carbonyl compounds and ammonia in presence of molecular hydrogen. Applying this Ni-based amination protocol, -NH2 moiety can be introduced in structurally complex compounds, for example, steroid derivatives and pharmaceuticals.