Effect of age on rabbit bladder function and structure following partial outlet obstruction.
Effect of age on rabbit bladder function and structure following partial outlet obstruction.
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年龄对部分出口梗阻后兔膀胱功能和结构的影响。
DOI：
10.1097/01.ju.0000149033.92717.93
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发表时间：
2005
期刊：
影响因子：
--
通讯作者：
Levin,RobertM
中科院分区：
文献类型：
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作者：
Agartan,CananAldirmaz;Whitbeck,Catherine;Chichester,Paul;Kogan,BarryA;Levin,RobertM
目的探讨青年兔和老年兔对部分膀胱出口梗阻的反应是否存在差异。材料与方法16只雄性新西兰白兔随机分为2组，每组8只。第1组为青年兔(7周龄)，第2组为老年兔(2岁)。每组4只兔接受部分出口梗阻，4只接受假手术。术后4周，取单个膀胱条进行收缩研究，对剩余组织进行组织学检查。结果青年组和老年假手术组对各种刺激的收缩反应相似。2个梗阻组对各种刺激的收缩反应均有不同程度的降低。然而，在年轻膀胱和老年膀胱中，张力产生对场刺激的比率下降的程度明显更大。尽管年轻兔和老年兔的膀胱均表现为平滑肌肥大，但老年兔的浆膜增厚程度明显高于年轻兔。幼兔表现出明显的炎症、出血和固有层扩张，而老年兔则没有这些特征。结论虽然幼兔和老年兔对梗阻的生理反应差异不大，但幼兔的组织学损伤程度明显较大。这可能是由于管壁较薄，对扩张更敏感。
PurposeWe determined whether young and old rabbits respond differently to partial bladder outlet obstruction.Materials and MethodsA total of 16 male New Zealand White rabbits were separated into 2 groups of 8 each. Group 1 consisted of young rabbits (age 7 weeks) and group 2 consisted of old rabbits (age 2 years). Four rabbits per group underwent partial outlet obstructions and 4 underwent sham operation. Four weeks following surgery individual bladder strips were used for contractile studies and the remaining tissue was examined histologically.ResultsContractile responses to all forms of stimulation between the young and old sham operated groups were similar. Contractile responses to all forms of stimulation were significantly decreased to the same degree in the 2 obstructed groups. However, the rate of tension generation to field stimulation was decreased to a significantly greater degree in young vs old bladders. Although young and old bladders showed smooth muscle hypertrophy, older rabbits showed significantly greater thickening of the serosa than young rabbits. Young rabbits showed significant inflammation, hemorrhage and expansion of the lamina propria, whereas old rabbits showed none of these characteristics.ConclusionsAlthough there were only minor differences in the physiological response of young and old bladders to obstruction, young rabbits showed a significantly greater degree of histological damage. This may have been due to the thinner wall and greater sensitivity to distention.