Low-cost, Implantable Wireless Sensor Platform for Neuromodulation Research.
Low-cost, Implantable Wireless Sensor Platform for Neuromodulation Research.
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用于神经调节研究的低成本、植入式无线传感器平台。
DOI：
10.1109/biocas.2018.8584729
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发表时间：
2018
期刊：
影响因子：
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通讯作者：
Majerus,SteveJA
中科院分区：
文献类型：
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作者：
McAdams,Ian;Kenyon,Hannah;Bourbeau,Dennis;Damaser,MargotS;Zorman,Christian;Majerus,SteveJA
周围神经在健康和疾病中调节主要器官功能的作用还不清楚。阐明生物标志物和自由形式麻醉条件下的神经活动之间的关系对于推进自主器官控制的未来研究和提高神经调节治疗方法的精度至关重要。在这里，我们提出了一个简单的，可定制的，现成的组件传感器平台，以满足研究有意识的，自由运动下的不同器官的研究需求。该平台由一个小型可充电纽扣电池、一个能量收集IC、一个低功耗微控制器、一个低功耗压力传感器、可定制数量的共阳极电极、感应充电输入和OOK感应传输组成。一个案例研究表明膀胱植入长期监测，利用一种新的，非密封封装的方法。该定制平台使用两种休眠模式来最大限度地减少电池负载，在检测和传输期间，最大时间平均电流消耗为125微安，微控制器的静态电流消耗为95纳安。
The role of peripheral nerves in regulating major organ function in health and disease is not well understood. Elucidating the relationships between biomarkers and neural activity during conditions free form anesthesia is essential to advancing future investigations of autonomic organ control and improving precision for neuromodulation treatment approaches. Here we present a simple, customizable, off-the-shelf component sensor platform to meet research needs for studying different organs under conscious, free movement. The platform consists of a small, rechargeable coin-cell battery, an energy-harvesting IC, a low-power microcontroller, a low-power pressure transducer, customizable number of electrodes with a common anode, inductive recharge input, and OOK inductive transmission. A case study demonstrating a bladder implant for long-term monitoring is presented, utilizing a novel, non-hermetic encapsulation approach. The customized platform uses two sleep modes to minimize battery loading, exhibiting a maximum time-averaged current draw of 125 micro-amps during sensing and transmission, with a quiescent current draw of 95 nano-amps into the microcontroller.