Risk factors for hepatocellular carcinoma in Hepatitis C patients with sustained virologic response to interferon therapy
Risk factors for hepatocellular carcinoma in Hepatitis C patients with sustained virologic response to interferon therapy
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DOI：
10.1111/j.1478-3231.2004.0956.x
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发表时间：
2004-12-01
影响因子：
6.7
通讯作者：
Shiratori, Y
中科院分区：
文献类型：
--
作者：
Iwasaki, Y;Takaguchi, K;Shiratori, Y
背景：尽管有多种文献表明干扰素治疗慢性丙型肝炎可抑制肝细胞癌的发生，但即使在持续的病毒学应答者中仍可观察到少量的肝细胞癌。目的：为了阐明影响肝细胞癌发生的因素，我们分析了持续病毒学应答人员在长期观察期内肝细胞癌的发生率。方法：在接受干扰素治疗的2 623例丙型肝炎患者中，有792例出现持续的病毒学应答。在平均5.1年的随访期内定期进行肝细胞癌的筛查。对预处理后的肝活检标本进行纤维化分级。采用COX比例风险回归分析肝癌的危险因素。结果：792例患者中，23例发展为肝癌。单因素分析显示，肝纤维化分期、年龄和饮酒与患肝癌的风险显著相关(P
Background: Although a variety of papers demonstrated inhibited hepatocarcinogenesis with interferon (IFN) therapy for chronic hepatitis C, a small number of hepatocellular carcinomas (HCCs) were still observed even in sustained virologic responders. Aims: To clarify factors affecting the development of HCC, we analyzed the frequency of HCC in sustained virologic responders over a long-term observation period. Methods: Seven hundred and ninety-two out of the 2623 IFN-treated hepatitis C patients who had undergone liver biopsy showed sustained virologic response. Screening for development of HCC was performed periodically during an average follow-up of 5.1 years. Fibrosis of the pretreatment liver biopsy sample was graded. Risk factors for HCC were analyzed by using Cox proportional hazards regression. Results: Of 792 patients, 23 developed HCC. Univariate analysis showed that stage of hepatic fibrosis, age, and alcohol consumption were significantly associated with a risk of HCC (P