Vitamin supplementation reduces the level of homocysteine in the urine of autistic children
Vitamin supplementation reduces the level of homocysteine in the urine of autistic children
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DOI：
10.1016/j.nutres.2011.03.009
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发表时间：
2011-04-01
影响因子：
4.5
通讯作者：
Rynkowski, Jacek
中科院分区：
文献类型：
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作者：
Kaluzna-Czaplinska, Joanna;Michalska, Monika;Rynkowski, Jacek
自闭症儿童尿中同型半胱氨酸水平的显着差异。我们假设补充维生素可能会降低尿同型半胱氨酸水平。为了使这种假设合理化，使用气相色谱/质谱法进行分析。两次测量孤独症儿童尿液中的同型半胱氨酸水平：（1）补充维生素前（C组，30名孤独症儿童）和（2）补充叶酸和维生素B-6和B-12（A1组，24名孤独症儿童）或单独补充维生素B-6和B12（A2组，6名孤独症儿童）后。在维生素补充前，自闭症儿童的尿中同型半胱氨酸水平为2.41 +/- 1.10 mmol/mol肌酐（平均值+/- SD差异）。治疗后，A1和A2组的同型半胱氨酸水平分别降至1.13 +/- 0.44和1.33 +/- 0.39 mmol/mol肌酐。发现维生素B-6和B-12与叶酸一起摄入比单独摄入维生素B-6和B-12更有效地降低尿同型半胱氨酸水平。我们的研究结果可能会导致建议在自闭症儿童的饮食中添加维生素B-6和B-12以及叶酸补充剂。(C)2011 Elsevier Inc. All rights reserved.
Significant differences in homocysteine levels in the urine of autistic children are observed. We hypothesized that vitamin supplementation might reduce the level of urinary homocysteine. To rationalize such a hypothesis, analyses were performed using the gas chromatography/mass spectrometry method. The homocysteine level in the urine of autistic children was measured twice: (1) before vitamin supplementation (group C, 30 autistic children) and (2) after supplementation, with either folic acid and vitamins B-6 and B-12 (group A1, 24 autistic children) or vitamins B-6 and B12 alone (group A2, 6 autistic children). The homocysteine level in the urine of autistic children before vitamin supplementation was 2.41 +/- 1.10 mmol/mol creatinine (mean +/- SD difference). After treatment, the homocysteine level was reduced to 1.13 +/- 0.44 and 1.33 +/- 0.39 mmol/mol creatinine for A1 and A2 groups, respectively. The intake of vitamins B-6 and B-12, together with folic acid, was found to be more effective in lowering the levels of urinary homocysteine than the intake of vitamins B-6 and B-12 alone. Our findings may lead to the recommendation of including vitamins B-6 and B-12 together with folic acid supplementation in the diets of children with autism. (C) 2011 Elsevier Inc. All rights reserved.