Glucocorticoids and the development of neuronal function: effects of prenatal dexamethasone exposure on central noradrenergic activity.
Glucocorticoids and the development of neuronal function: effects of prenatal dexamethasone exposure on central noradrenergic activity.
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糖皮质激素和神经元功能的发育：产前地塞米松暴露对中枢去甲肾上腺素能活性的影响。
DOI：
10.1159/000243761
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发表时间：
1992
期刊：
影响因子：
--
通讯作者：
F. Seidler
中科院分区：
文献类型：
--
作者：
T. Slotkin;S. Lappi;E. McCook;M. I. Tayyeb;J. Eylers;F. Seidler
虽然糖皮质激素减缓大多数细胞类型的发育，但它们已被假设为促进儿茶酚胺能细胞的分化。在目前的研究中，孕鼠给予地塞米松在妊娠第17，18和19天，和去甲肾上腺素能突触活动的功能状态进行了评估，通过测量发射水平和营业额，和受体结合能力在整个出生后的发展。尽管地塞米松引起的生长抑制，类固醇治疗对递质水平或受体结合几乎没有影响，并以区域选择性方式加速去甲肾上腺素周转的成熟。影响在中脑和脑干中最为显著，其中周转率比对照组提前1-2周达到最高水平。在地塞米松组中，周转率也过早地趋于平稳，导致断奶后和成年早期的赤字。虽然在其他较晚发展的地区也获得了类似的模式，但效果不太一致和稳健;较小的影响也延伸到多巴胺周转。这些结果表明，糖皮质激素有一个特定的促进作用的发展，中央儿茶酚胺能活性和外源性类固醇的管理在发展的关键时期可能会导致持久的功能异常。
Although glucocorticoids slow the development of most cell types, they have been hypothesized to promote the differentiation of catecholaminergic cells. In the current study, pregnant rats were given dexamethasone on gestational days 17, 18 and 19, and the functional state of noradrenergic synaptic activity was assessed throughout postnatal development by measurements of transmitter levels and turnover, and receptor binding capabilities. Despite growth inhibition caused by dexamethasone, the steroid treatment had little or no effect on transmitter levels or receptor binding and accelerated the maturation of norepinephrine turnover in a regionally selective manner. Effects were most notable in the midbrain and brainstem, where turnover rose to maximum levels 1-2 weeks in advance of controls. Turnover also leveled off prematurely in the dexamethasone group, leading to deficits in the postweaning period and into young adulthood. Although similar patterns were obtained in other, later-developing regions, the effects were less consistent and robust; the smaller effects also extended to dopamine turnover. These results suggest that glucocorticoids have a specific promotional effect on the development of central catecholaminergic activity and that administration of exogenous steroids during critical periods of development can lead to lasting functional abnormalities.