Notch and NFκB signaling pathways:: do they collaborate in normal vertebrate brain development and function?
Notch and NFκB signaling pathways:: do they collaborate in normal vertebrate brain development and function?
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DOI：
10.1002/bies.20647
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发表时间：
2007-10-01
期刊：
影响因子：
4
通讯作者：
Tergaonkar, Vinay
中科院分区：
文献类型：
--
作者：
Ang, Hwee-Luan;Tergaonkar, Vinay
Notch和NF-kappa B信号通路都是众所周知的调节细胞增殖、分化和凋亡的信号通路。最近的研究已经提出了几条证据，支持在一系列不同类型的细胞分化/成熟过程中整合Notch和NF-kappa B信号通路。值得注意的是，Notch和NF kappa B信号通路有许多共同的特征：(I)都被常见的刺激，如肿瘤坏死因子-α和低氧激活，(Ii)激活的Notch(NICD)和NF kappa B通过调节辅阻遏物如SMRT/N-COR来调节转录，以及(Iii)都调节相似的靶基因，如Hes-1和I kappa Bα。这篇综述扩展了这些通路之间的合作如何在中枢神经系统中发挥重要作用。我们将推测Notch和NF-kappa B信号在大脑发育和功能过程中协同调节干细胞更新和分化的机制。
Both Notch and NF kappa B signaling pathways are well-known for regulating proliferation, differentiation and apoptosis. Recent studies have presented several lines of evidence supporting an integration of the Notch and NF kappa B signaling pathways in differentiation/maturation of a diverse range of cell types. It is notable that Notch and NF kappa B signaling pathways share many common features: (i) both are activated by common stimuli such as TNF-alpha and hypoxia, (ii) activated Notch (NICD) and NF kappa B mediate transcription by regulating corepressors such as SMRT/N-COR, and (iii) both regulate similar target genes such as Hes-1 and I kappa B alpha. This review expands on how the collaboration between these pathways may play an important role in the CNS. We will speculate on the mechanisms by which Notch and NF kappa B signaling may collaborate to regulate stem cell renewal and differentiation during brain development and function.