Prepulse Inhibition of Auditory Cortical Responses in the Caudolateral Superior Temporal Gyrus in Macaca mulatta
Prepulse Inhibition of Auditory Cortical Responses in the Caudolateral Superior Temporal Gyrus in Macaca mulatta
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DOI：
10.1007/s12264-017-0181-7
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发表时间：
2018-04-01
影响因子：
5.6
通讯作者：
Carlson, Synnove
中科院分区：
文献类型：
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作者：
Chen, Zuyue;Parkkonen, Lauri;Carlson, Synnove
前脉冲抑制（PPI）是指当一个较弱的刺激先于另一个较弱的刺激时，对一个惊吓刺激的反应减弱的现象。我们记录了四只猴子的局部场电位（LFPs），并研究了听觉皮层反应（α，β和γ振荡和诱发电位）的PPI是否可以在上级颞回（STGcb）的尾外侧带显示。我们还调查了是否存在同种，这将注意力从听觉刺激，影响PPI的听觉皮层反应。PPI范例包括仅脉冲试验和前脉冲+脉冲试验，在猴子单独（ALONE）和另一只猴子在同一房间（ACCOMP）时随机提供。脉冲的LFPs被预脉冲显著抑制，因此证明了STGcb中皮质反应的PPI。PPI相关的抑制N1振幅的诱发反应和皮层振荡的脉冲不受同种的存在。相比之下，与单独条件相比，ACCOMP条件下仅脉冲的伽马振荡和N1响应幅度受到抑制。这些研究结果表明，PPI在猴子STGcb的听觉皮层反应的PPI在猴子STGcb是一个前注意的抑制过程，是独立的注意调制。
Prepulse inhibition (PPI) refers to a decreased response to a startling stimulus when another weaker stimulus precedes it. Most PPI studies have focused on the physiological startle reflex and fewer have reported the PPI of cortical responses. We recorded local field potentials (LFPs) in four monkeys and investigated whether the PPI of auditory cortical responses (alpha, beta, and gamma oscillations and evoked potentials) can be demonstrated in the caudolateral belt of the superior temporal gyrus (STGcb). We also investigated whether the presence of a conspecific, which draws attention away from the auditory stimuli, affects the PPI of auditory cortical responses. The PPI paradigm consisted of Pulse-only and Prepulse + Pulse trials that were presented randomly while the monkey was alone (ALONE) and while another monkey was present in the same room (ACCOMP). The LFPs to the Pulse were significantly suppressed by the Prepulse thus, demonstrating PPI of cortical responses in the STGcb. The PPI-related inhibition of the N1 amplitude of the evoked responses and cortical oscillations to the Pulse were not affected by the presence of a conspecific. In contrast, gamma oscillations and the amplitude of the N1 response to Pulse-only were suppressed in the ACCOMP condition compared to the ALONE condition. These findings demonstrate PPI in the monkey STGcb and suggest that the PPI of auditory cortical responses in the monkey STGcb is a pre-attentive inhibitory process that is independent of attentional modulation.