Prognostic value of OCT4 in primary intracranial germinoma: a single institute analysis of 31 cases
Prognostic value of OCT4 in primary intracranial germinoma: a single institute analysis of 31 cases
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OCT4对原发性颅内生殖细胞瘤的预后价值：31例单机构分析
DOI：
10.3109/02688697.2011.605483
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发表时间：
2012-04-01
影响因子：
1.1
通讯作者：
Li, Qiaoyu
中科院分区：
文献类型：
--
作者：
Wanggou, Siyi;Jiang, Xingjun;Li, Qiaoyu
摘要OCT 4在颅内原发性生殖细胞瘤中表达。在这项研究中，我们验证了我们的假设，OCT 4的这种变化是预测原发性颅内生殖细胞瘤的结果。31例经组织学鉴定的CNS生殖细胞瘤患者入组本研究。从2001年4月至2010年5月，我们收集了医疗数据，化学分析评估了OCT 4表达水平，并对所有患者进行了随访。我们发现31例患者中有7例OCT 4弱表达，11例OCT 4中度表达，13例OCT 4强表达。OCT 4表达水平与临床病理特征无明显相关性。WV-CS联合治疗方式显示出比其他治疗方式更好的5年无进展生存率（PFS），并且OCT 4的低表达水平显示出显著更好的5年PFS。在WV-CS联合治疗模式和其他治疗模式组中，患者的5年PFS更好，OCT 4表达水平更低。因此，我们建议OCT 4作为颅内生殖细胞瘤的一个可能的预后指标。
Abstract OCT4 expresses variably in primary intracranial germinomas. In this study, we tested our hypothesis that such variation of OCT4 is predictive of outcome in primary intracranial germinomas. Thirty-one histologically identified CNS germinoma patients were enrolled in our study. We collected medical data, immunohistochemically evaluated the OCT4 expression level, and followed up all patients from April 2001 to May 2010. We found that 7 of the 31 patients expressed OCT4 weakly, 11 expressed OCT4 moderately, and 13 expressed OCT4 strongly. No significant correlation between the OCT4 expression level and clinicopathological characteristics was observed. WV-CS combined treatment modality showed a better 5-year progression-free survival (PFS) rate than other treatment modalities and a low expression level of OCT4 showed a significantly better 5-year PFS. In both the WV-CS combined treatment modality and other treatments modality group, patients received a better 5-year PFS and had a lower level of OCT4 expression. As a result, we suggest OCT4 as a probable prognostic marker for intracranial germinoma.