Chromatin structure of pluripotent stem cells and induced pluripotent stem cells
Chromatin structure of pluripotent stem cells and induced pluripotent stem cells
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DOI：
10.1093/bfgp/elq038
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发表时间：
2011-01-01
影响因子：
4
通讯作者：
Recillas-Targa, Felix
中科院分区：
文献类型：
--
作者：
Delgado-Olguin, Paul;Recillas-Targa, Felix
多能胚胎干细胞是一种具有动态染色质结构的特化细胞，与其多能性和生理学密切相关。近年来，体细胞通过过度表达一组确定的转录因子而被重新编程为多能状态。这些细胞被称为诱导多能干细胞(IPS)，概括了ES细胞的特性，显然可以分化为所有细胞系，使iPS细胞成为未来再生医学中ES细胞的合适替代品。染色质修饰物在建立和维持多能性方面起着关键作用，因此，阐明ES和iPS细胞中染色质结构的控制机制对于了解它们的特性和利用它们的治疗潜力是至关重要的。在这篇综述中，我们讨论了最近的研究，这些研究提供了ES细胞和iPS细胞中染色质结构特征的全基因组视角，并强调了组蛋白修饰物和染色质重构体在多能性维持和诱导中的核心作用。
Pluripotent embryonic stem (ES) cells are specialized cells with a dynamic chromatin structure, which is intimately connected with their pluripotency and physiology. In recent years somatic cells have been reprogrammed to a pluripotent state through over-expression of a defined set of transcription factors. These cells, known as induced pluripotent stem (iPS) cells, recapitulate ES cell properties and can be differentiated to apparently all cell lineages, making iPS cells a suitable replacement for ES cells in future regenerative medicine. Chromatin modifiers play a key function in establishing and maintaining pluripotency, therefore, elucidating the mechanisms controlling chromatin structure in both ES and iPS cells is of utmost importance to understanding their properties and harnessing their therapeutic potential. In this review, we discuss recent studies that provide a genome-wide view of the chromatin structure signature in ES cells and iPS cells and that highlight the central role of histone modifiers and chromatin remodelers in pluripotency maintenance and induction.