Early increases in coronary vascular reserve in exercised rats are independent of cardiac hypertrophy.
Early increases in coronary vascular reserve in exercised rats are independent of cardiac hypertrophy.
复制标题
运动大鼠冠状血管储备的早期增加与心脏肥大无关。
DOI：
10.1152/jappl.1985.59.6.1861
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发表时间：
1985
期刊：
影响因子：
--
通讯作者：
Scheuer,J
中科院分区：
文献类型：
--
作者：
Buttrick,PM;Levite,HA;Schaible,TF;Ciambrone,G;Scheuer,J
为了评估与体育训练相关的生理性心肌肥大与与这种刺激相关的血管电容增加之间的关系，研究了通过游泳项目训练的雄性和雌性大鼠。为了研究冠状动脉血管对运动的反应，我们使用了两种性别的受试者，分别是存在（女性）和不存在（男性）心肌肥厚。在最小冠状动脉阻力（15微克腺苷或缺氧）条件下，评估离体逆行缓冲灌注心脏的冠状动脉血管储备。经过8周的运动游泳训练，两组动物的冠状动脉储备都有所增加，雄性动物的心肌流量（每克心肌）增加了15%，雌性动物增加了18%。当将雌性动物的这种反应的时间过程与心肌肥大的发展时间过程进行比较时，很明显，血管的变化发生得很早，在运动的前10天内观察到超过80%的反应，而心脏质量增加了约35%。这些数据表明，运动游泳训练的血管反应独立于肥厚反应，进一步表明冠状动脉血管的增加是心脏适应生理负荷的早期事件。
To evaluate the relationship between the physiological cardiac hypertrophy associated with physical training and the increases in vascular capacitance associated with this stimuli, male and female rats trained by a swimming program were studied. Both sexes were used so that the coronary vascular response to exercise could be studied in the presence (females) and absence (males) of cardiac hypertrophy. Coronary vascular reserve was assessed in isolated retrograde buffer-perfused hearts under conditions of minimal coronary resistance (15 microM adenosine or anoxia). Both groups demonstrated an increase in coronary vascular reserve after 8 wk of exercise swim training, male animals increasing flow (per g of myocardium) by 15% and females by 18%. When the time course of this response was compared in female animals with the time course of the development of myocardial hypertrophy, it was evident that the vascular changes occurred early, greater than 80% of the response was seen within the first 10 days of exercise, compared with an approximately 35% increase in cardiac mass. These data suggest that the vascular response to exercise swim training is independent of the hypertrophic response and further that the increase in coronary vascularity is an early event in the cardiac adaptation to a physiological load.