Gallic acid: Molecular rival of cancer
Gallic acid: Molecular rival of cancer
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DOI：
10.1016/j.etap.2013.02.011
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发表时间：
2013-05-01
影响因子：
4.3
通讯作者：
Mishra, Abha
中科院分区：
文献类型：
--
作者：
Verma, Sharad;Singh, Amit;Mishra, Abha
没食子酸是一种主要的多酚，已显示在动物模型和体外癌细胞系中抑制致癌作用。没食子酸对癌细胞生长的抑制作用是通过调节编码细胞周期、转移、血管生成和凋亡的基因来介导的。没食子酸抑制NF-κ B和Akt信号通路的活化沿着考克斯、核糖核苷酸还原酶和GSH的活性。此外，没食子酸激活ATM激酶信号通路，以防止致癌过程。迄今为止，从体内和体外研究中获得的数据表明，这种膳食多酚可能是癌症化学预防领域有前途的试剂。(c)2013爱思唯尔有限公司版权所有。
Gallic acid, a predominant polyphenol, has been shown to inhibit carcinogenesis in animal models and in vitro cancerous cell lines. The inhibitory effect of gallic acid on cancer cell growth is mediated via the modulation of genes which encodes for cell cycle, metastasis, angiogenesis and apoptosis. Gallic acid inhibits activation of NF-kappa B and Akt signaling pathways along with the activity of COX, ribonucleotide reductase and GSH. Moreover, gallic acid activates ATM kinase signaling pathways to prevent the processes of carcinogenesis. The data so far available, both from in vivo and in vitro studies, indicate that this dietary polyphenol could be promising agent in the field of cancer chemoprevention. (c) 2013 Elsevier B.V. All rights reserved.