Echocardiographic insights into regional flow-function relationships in coronary artery disease.
Echocardiographic insights into regional flow-function relationships in coronary artery disease.
复制标题
超声心动图对冠状动脉疾病局部血流功能关系的见解。
DOI：
10.1016/j.nuclcard.2005.01.003
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发表时间：
2005
期刊：
影响因子：
--
通讯作者：
Kaul,Sanjiv
中科院分区：
文献类型：
--
作者：
Kaul,Sanjiv
The literature on regional flow-function relationships in coronary artery disease (CAD) is too large to review here. Instead, I shall review some of the salient features of these relationships as defined by echocardiography. The data discussed are from acute and chronic canine models of CAD as well as from human beings. The canine chronic coronary stenosis model is developed by placing ameroid constrictors on the major coronary arteries and their major branches, and data are generally collected after 6 weeks or later when left ventricular (LV) dysfunction has developed. 1 The wall thickening (WT) data in the review are derived mostly from 2-dimensional echocardiography and the perfusion data are derived from myocardial contrast echocardiography (MCE), the technical aspects of which are briefly discussed first.WT remains the principal measurement for regional function analysis on echocardiography. It is better to measure WT than wall motion for 2 major reasons. First, motion is affected by the LV loading conditions. Thus nonfunctioning myocardium can appear to move without really thickening. Second, to measure wall motion, there must be a center of reference (usually in the LV cavity) from which measurements can be made. Because of respiration-induced cardiac translation, the left ventricle moves and therefore it is not possible to have a static reference. A floating reference that moves with the left ventricle or a fixed reference that does not will tend to overestimate or underestimate the circumferential extent of abnormal wall motion depending on whether the heart is moving toward or away from the reference. 2 A “centroid” reference that is averaged from the LV cavity
