Ontogeny of dopamine daily rhythms within rabbit brainstem regions.
Ontogeny of dopamine daily rhythms within rabbit brainstem regions.
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兔脑干区域多巴胺日节律的个体发育。
DOI：
10.1159/000244176
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发表时间：
1995
期刊：
影响因子：
--
通讯作者：
McNamara,MC
中科院分区：
文献类型：
--
作者：
Gingras,JL;Lawson,EE;McNamara,MC
为了研究多巴胺水平日变化的发展，我们测量了3日龄和21日龄成年兔和成年兔09.30、15.30、21.30和03.30h脑干五个不同区域的多巴胺浓度，并用放射酶方法测定了多巴胺浓度，并以湿组织重量表示。除了确定整个脑干中多巴胺浓度的每日变化的存在之外，我们感兴趣的是在这种每日变化中确定脑干区域特定的差异。我们的数据表明，多巴胺浓度的每日变化是在生命的3天内确定的。对粗略的脑干日变化数据的分析表明，3日龄动物的多巴胺浓度在早期光照阶段(09.30h)达到峰值，而21日龄动物的后期光照阶段达到峰值(15.30h)。成年动物在暗期早期(21.30h)出现一个高峰。这些总的日变化反映了多巴胺浓度中不同地区特定模式的净和。按地区进行的分析反映了多巴胺日变化发展的地区特有的个体发生。多巴胺参与心肺调节。观察到的发育模式可能与这些生理过程的成熟和整合有关。
To examine the development of daily variations in dopamine levels, we measured dopamine concentrations within five distinct brainstem regions in 3- and 21-day-old, and adult rabbits at 09.30, 15.30, 21.30 and 03.30 h. Dopamine was measured by radioenzymatic assay and the dopamine concentration was expressed relative to wet tissue weight. In addition to defining the presence of a daily variation in the dopamine concentration in the whole brainstem, we were interested in identifying brainstem region-specific differences in this daily variation. Our data suggest that daily variations in dopamine concentrations are established by 3 days of life. Analysis of gross brainstem daily variation data suggest a peak in the dopamine concentration during the early light phase (09.30 h) for 3-day-old animals in contrast to a late light phase peak (15.30 h) for 21-day-old animals. Adult animals showed a peak in the early dark phase (21.30 h). These gross daily variations reflect the net sum of distinct region-specific patterns in the dopamine concentration. Analysis by region reflects a region-specific ontogeny in the development of daily variations for dopamine. Dopamine is involved in cardiorespiratory regulation. The observed developmental patterns may relate to the maturation and integration of these physiologic processes.