Prediction of childhood obesity by infancy weight gain: an individual-level meta-analysis
Prediction of childhood obesity by infancy weight gain: an individual-level meta-analysis
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DOI：
10.1111/j.1365-3016.2011.01213.x
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发表时间：
2012-01-01
影响因子：
2.8
通讯作者：
Ong, Ken K.
中科院分区：
文献类型：
--
作者：
Druet, Celine;Stettler, Nicolas;Ong, Ken K.
为了评估婴儿体重增加对随后肥胖的预测能力，我们对来自英国、法国、芬兰、瑞典、美国和塞舌尔的10项队列研究的47661名参与者的个人数据进行了荟萃分析。使用相同的外部参考资料（British 1990）计算每个个体出生时和1岁时的体重SD评分。儿童肥胖是根据国际肥胖工作组的标准定义的。在0至1岁之间，体重SD评分每增加1个单位，儿童肥胖的风险增加两倍（优势比= 1.97[95%可信区间（CI） 1.83, 2.12]），成人肥胖的风险增加23%（优势比= 1.23[1.16,1.30]），经性别、年龄和出生体重调整后。研究之间几乎没有异质性。从具有可用信息的普通人群队列中随机选择50%的个体（n = 8236），生成儿童肥胖风险评分，包括0-1岁体重增加、母亲体重指数、出生体重和性别；该评分在其余50%的样本中显示中等的预测能力（接受工作曲线下面积= 77% [95% CI 74,80%]）。儿童超重的单独风险评分也显示出类似的预测能力（接受手术曲线下面积= 76%[73,79%]）。总之，婴儿体重增加与随后的肥胖呈一致的正相关。结合出生体重和婴儿体重增加（或仅仅是婴儿体重）的风险评分，再加上母亲的体重指数和性别，可以对儿童肥胖风险的婴儿进行早期分层。
To assess the predictive ability of infant weight gain on subsequent obesity we performed a meta-analysis of individual-level data on 47 661 participants from 10 cohort studies from the UK, France, Finland, Sweden, the US and Seychelles. For each individual, weight SD scores at birth and age 1 year were calculated using the same external reference (British 1990). Childhood obesity was defined by International Obesity Task Force criteria. Each +1 unit increase in weight SD scores between 0 and 1 year conferred a twofold higher risk of childhood obesity (odds ratio = 1.97 [95% confidence interval (CI) 1.83, 2.12]), and a 23% higher risk of adult obesity (odds ratio = 1.23 [1.16, 1.30]), adjusted for sex, age and birthweight. There was little heterogeneity between studies. A risk score for childhood obesity comprising weight gain 0-1 year, mother's body mass index, birthweight and sex was generated in a random 50% selection of individuals from general population cohorts with available information (n = 8236); this score showed moderate predictive ability in the remaining 50% sample (area under receiving operating curve = 77% [95% CI 74, 80%]). A separate risk score for childhood overweight showed similar predictive ability (area under receiving operating curve = 76% [73, 79%]). In conclusion, infant weight gain showed a consistent positive association with subsequent obesity. A risk score combining birthweight and infant weight gain (or simply infant weight), together with mother's body mass index and sex may allow early stratification of infants at risk of childhood obesity.