Some immunological considerations in liver transplantation.
Some immunological considerations in liver transplantation.
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肝移植中的一些免疫学考虑。
DOI：
10.1002/hep.1840040720
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发表时间：
1984
期刊：
影响因子：
--
通讯作者：
Russell,PS
中科院分区：
文献类型：
--
作者：
Russell,PS
特别感兴趣的免疫学考虑肝移植检查。它的结论是，人类之间的肝移植产生典型的排斥反应，虽然他们可能会，总体而言，比那些在移植肾脏和心脏中遇到的更温和。有些动物就是这种情况，原因尚不清楚。有证据表明，移植的肝脏比其他器官更容易受到免疫攻击。无论是移植物vs.-宿主活性是否具有临床重要性尚不确定。环孢菌素免疫抑制剂的出现改善了肝脏受者的前景，但免疫抑制剂的多种并发症仍会发生，需要熟练的管理。
Immunological considerations of special interest in liver transplantation are examined. It is concluded that liver transplants between human beings generate typical rejection reactions although they may, overall, be somewhat more mild than those encountered in transplanted kidneys and hearts. This is the case in some animals for reasons which are not yet clear. There is evidence that the transplanted liver can suffer immune attack better than other organs. Whether graft-vs.-host activity is of clinical importance is uncertain. The advent of cyclosporin immunosuppression has improved the outlook for liver recipients but multiple complications of immunosuppression will still occur and demand skillful management.