Modulation of the Default Mode Network in First-Episode, Drug-Naïve Major Depressive Disorder via Acupuncture at Baihui (GV20) Acupoint.
Modulation of the Default Mode Network in First-Episode, Drug-Naïve Major Depressive Disorder via Acupuncture at Baihui (GV20) Acupoint.
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针刺百会（GV2O）穴位调节首发吸毒型重度抑郁症的默认模式网络
DOI：
10.3389/fnhum.2016.00230
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发表时间：
2016
影响因子：
2.9
通讯作者：
Tao J
中科院分区：
文献类型：
--
作者：
Deng D;Liao H;Duan G;Liu Y;He Q;Liu H;Tang L;Pang Y;Tao J
背景资料：以往的神经影像学研究表明，针灸调制默认模式网络（DMN）在健康受试者和某些疾病的患者。然而，很少有研究已经进行了调查，是否针灸可能会调节重性抑郁症（MDD）患者的DMN。因此，本研究的目的是评估首次发作，药物初治MDD患者的针刺刺激引起的DMN的改变。材料和方法：29例首次发作的药物初治MDD患者和29例健康受试者入选本研究。所有健康受试者均行静息状态下功能磁共振成像（R-fMRI）扫描。电针治疗前和治疗后分别进行2次6 min R-fMRI扫描。以楔前叶/后扣带皮层（PC/PCC）为种子区，采用功能连接（FC）方法检测MDD患者DMN的异常，并与健康人进行比较，评价EAS对MDD患者DMN内在连接的影响。结果：与正常人相比，MDD患者DMN异常。结果显示，在GV 20时，抑郁症患者PC/PCC与双侧前扣带皮层（ACC）之间的FC增加，而与左侧中前额叶皮层、左侧角回和双侧海马/海马旁区（HIPP/paraHIPP）之间的FC减少，这是抑郁症患者与健康人之间存在显著差异的主要脑区。结论：我们的研究结果提供了影像学证据，支持GV 20相关的针刺刺激可能会调节首次发作，药物初治MDD患者的DMN。本研究为临床上针刺GV 20治疗抑郁症的神经机制提供了部分理论依据。
Background: Previous neuroimaging studies have revealed that acupuncture modulates the default mode network (DMN) in healthy subjects and patients with certain disorder. However, few studies have been performed to investigate whether or not acupuncture might modulate the DMN in patients with major depressive disorder (MDD). Thereby, the aim of the present study was to assess alterations of the DMN induced by acupuncture stimulation in patients with first-episode, drug-naïve MDD. Materials and Methods: Twenty nine patients with first-episode, drug-naïve MDD and 29 healthy subjects were enrolled in this study. All the healthy subjects underwent 6-min resting-state functional magnetic resonance imaging (R-fMRI) scan. While patients underwent acupuncture stimulation for 20-min electro-acupuncture stimulation (EAS) at Baihui acupoint (GV20) and two 6-min R-fMRI scans before and after EAS. Based on the precuneus/posterior cingulate cortex (PC/PCC) as the seed region, functional connectivity (FC) method was adopted to examine abnormal DMN in patients by comparing with healthy subjects and to evaluate the influence of EAS on intrinsic connectivity within the DMN in patients with MDD. Results: Compared to healthy subjects, MDD patients had abnormal DMN. Moreover, results showed that EAS at GV20 induced increased FC between the PC/PCC and bilateral anterior cingulate cortex (ACC), and decreased FC between the PC/PCC and left middle prefrontal cortex, left angualr gyrus and bilateral hippocampus/parahippocampus (HIPP/paraHIPP) in patients with MDD, which were the main brain regions showing significant differences between the patients and healthy subjects. Conclusion: Our findings provide imaging evidence to support that GV20-related acupuncture stimulation may modulate the DMN in patients with first-episode, drug-naïve MDD. This study may partly interpret the neural mechanisms of acupuncture at GV20 which is used to treat patients with MDD in clinical.