THE BASIC-HELIX-LOOP-HELIX DOMAIN OF DROSOPHILA LETHAL OF SCUTE PROTEIN IS SUFFICIENT FOR PRONEURAL FUNCTION AND ACTIVATES NEUROGENIC GENES
THE BASIC-HELIX-LOOP-HELIX DOMAIN OF DROSOPHILA LETHAL OF SCUTE PROTEIN IS SUFFICIENT FOR PRONEURAL FUNCTION AND ACTIVATES NEUROGENIC GENES
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DOI：
10.1016/0092-8674(94)90174-0
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发表时间：
1994-01-14
期刊：
影响因子：
64.5
通讯作者：
CAMPOSORTEGA, JA
中科院分区：
文献类型：
--
作者：
HINZ, U;GIEBEL, B;CAMPOSORTEGA, JA
果蝇大多数表皮感觉器官的发育是由无壳菌和盾片（无壳菌-盾片复合体（AS-C）的两个基因）控制的。 AS-C 的基因编码基本螺旋-环-螺旋 (bHLH) 类转录调节因子的成员，它们的活性定义了成虫盘中的原神经细胞簇，通过侧抑制过程从成虫盘中挑选出感觉器官母细胞。盾片的致死性（AS-C 的另一个成员）的异位表达通常对于成人感觉器官的发育是可有可无的，它独立于其他 AS-C 基因的活性而促进这一过程。这证明了 AS-C 产品的高度功能冗余。此外，异位原神经簇中的神经源基因被激活，从而允许表皮祖细胞发育。最后，bHLH 结构域对于介导原神经功能、激活神经源性基因和允许侧向抑制是必要且充分的。
The development of most epidermal sensory organs in Drosophila is controlled by achaete and scute, two of the genes of the achaete-scute complex (AS-C). The genes of the AS-C encode members of the basic-helix-loop-helix (bHLH) class of transcriptional regulators, and their activity defines proneural cell clusters in the imaginal discs from which sensory organ mother cells are singled out by a process of lateral inhibition. Ectopic expression of lethal of scute, another member of the AS-C, normally dispensable for sensory organ development in the adult, promotes this process independently of the activity of the other AS-C genes. This demonstrates a high degree of functional redundancy of the products of the AS-C. Furthermore, neurogenic genes are activated in ectopic proneural clusters, allowing development of epidermal progenitor cells. Finally, the bHLH domain is necessary and sufficient to mediate the proneural function, to activate neurogenic genes, and to allow lateral inhibition.