IgG autoantibodies to complement C1q in pediatric-onset systemic lupus erythematosus.
IgG autoantibodies to complement C1q in pediatric-onset systemic lupus erythematosus.
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发表时间：
1997-03
影响因子：
3.7
通讯作者：
A. Ravelli;J. Wisnieski;B. Ramenghi;G. Ballardini;L. Zonta;A. Martini
中科院分区：
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作者：
A. Ravelli;J. Wisnieski;B. Ramenghi;G. Ballardini;L. Zonta;A. Martini
目的 在高达 50% 的系统性红斑狼疮 (SLE) 成年患者中发现 C1q (aC1q) 抗体，并且与增殖性肾小球肾炎相关。我们调查了儿童 SLE 中 aC1q 的患病率和临床意义。方法 通过 ELISA 方法对 29 名儿童期发病的 SLE 患者（26 名女性和 3 名男性，年龄 7.5 至 19.6 岁）的 C1q 抗体进行了评估。结果 29 名患者中有 17 名 (59%) 最初 aC1q 呈阳性。未发现 aC1q 的存在或滴度与任何临床表现（包括肾炎）之间存在相关性。然而，aC1q 水平与抗双链 DNA 抗体和 C3 值之间存在显着相关性。 23 名患者的 aC1q 连续测定显示滴度进行性下降，几乎没有显着波动。 C1q 抗体并不是 SLE 活动增加的可靠预测因子，因为它们仅在 50% 的发作前血清中增加或可检测到。结论 在我们的儿童 SLE 患者中，C1q 抗体经常呈阳性，并且与疾病活动性的实验室变量相关。然而，与患有 SLE 的成人不同，在这些儿童患者中并未发现 aC1q 与肾小球肾炎之间存在高度相关性。
OBJECTIVE Antibodies to C1q (aC1q) have been found in up to 50% of adult patients with systemic lupus erythematosus (SLE) and have been associated with proliferative glomerulonephritis. We investigated the prevalence and clinical significance of aC1q in pediatric SLE. METHODS Antibodies to C1q, measured by an ELISA method, were evaluated in 29 patients with childhood-onset SLE, 26 females and 3 males, aged 7.5 to 19.6 years. RESULTS Seventeen (59%) of the 29 patients were initially positive for aC1q. No correlation was found between either the presence or titer of aC1q and any of the clinical manifestations, including nephritis. However, a significant correlation was observed between aC1q levels and anti-double-stranded DNA antibodies and C3 values. Serial determinations of aC1q in 23 patients showed a progressive decline in the titers with few significant fluctuations. Antibodies to C1q were not a reliable predictor of increased SLE activity, since they increased or became detectable in only 50% of the pre-flare sera. CONCLUSION Antibodies to C1q were frequently positive in our patients with pediatric SLE and were correlated with laboratory variables of disease activity. However, unlike in adults with SLE, a high correlation between aC1q and glomerulonephritis was not found in these pediatric patients.