Dose distributions in a human head phantom for neutron capture therapy using moderated neutrons from the 2.5 meV proton-7Li reaction or from fission of 235U.
Dose distributions in a human head phantom for neutron capture therapy using moderated neutrons from the 2.5 meV proton-7Li reaction or from fission of 235U.
复制标题
使用来自 2.5 meV 质子 7Li 反应或来自 235U 裂变的慢化中子进行中子捕获治疗的人体头部模型中的剂量分布。
DOI：
10.1088/0031-9155/46/10/311
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发表时间：
2001
影响因子：
3.5
通讯作者：
M. Hoshi
中科院分区：
文献类型：
--
作者：
K. Tanaka;T. Kobayashi;Y. Sakurai;Y. Nakagawa;S. Endo;M. Hoshi
研究了使用基于加速器的7 Li（p，通过比较广岛大学放射性研究加速器（HIRRAC）和京都大学反应堆重水中子辐照装置的中子束流，研究了2.5 MeV质子产生的核聚变反应（KUR-HWNIF）从快中子和γ射线的污染剂量比的观点。在直径为20 cm、长度为20 cm的水模体中估计硼剂量的污染比，以模拟人体头部，采用与KUR-HWNIF中NCT相同的技术进行实验和/或采用Monte Carlo N粒子输运代码系统版本4 B（MCNP-4 B）进行模拟计算。结果发现，由2.5 MeV质子产生的7 Li（p，n）中子与20，25或30 cm厚的直径为20 cm的D20慢化剂相结合，可以使NCT的辐照场具有与KUR-HWNIF的超热中子束相似的深度-剂量特性。
The feasibility of neutron capture therapy (NCT) using an accelerator-based neutron source of the 7Li(p,n) reaction produced by 2.5 MeV protons was investigated by comparing the neutron beam tailored by both the Hiroshima University radiological research accelerator (HIRRAC) and the heavy water neutron irradiation facility in the Kyoto University reactor (KUR-HWNIF) from the viewpoint of the contamination dose ratios of the fast neutrons and the gamma rays. These contamination ratios to the boron dose were estimated in a water phantom of 20 cm diameter and 20 cm length to simulate a human head, with experiments by the same techniques for NCT in KUR-HWNIF and/or the simulation calculations by the Monte Carlo N-particle transport code system version 4B (MCNP-4B). It was found that the 7Li(p,n) neutrons produced by 2.5 MeV protons combined with 20, 25 or 30 cm thick D20 moderators of 20 cm diameter could make irradiation fields for NCT with depth-dose characteristics similar to those from the epithermal neutron beam at the KUR-HWNIF.