Global patterns in genomic diversity underpinning the evolution of insecticide resistance in the aphid crop pest Myzus persicae.
Global patterns in genomic diversity underpinning the evolution of insecticide resistance in the aphid crop pest Myzus persicae.
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基因组多样性的全球模式支持蚜虫作物害虫桃蚜杀虫剂抗性的进化。
DOI：
10.1038/s42003-021-02373-x
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发表时间：
2021-07-07
影响因子：
5.9
通讯作者：
Bass C
中科院分区：
文献类型：
--
作者：
Singh KS;Cordeiro EMG;Troczka BJ;Pym A;Mackisack J;Mathers TC;Duarte A;Legeai F;Robin S;Bielza P;Burrack HJ;Charaabi K;Denholm I;Figueroa CC;Ffrench-Constant RH;Jander G;Margaritopoulos JT;Mazzoni E;Nauen R;Ramírez CC;Ren G;Stepanyan I;Umina PA;Voronova NV;Vontas J;Williamson MS;Wilson ACC;Xi-Wu G;Youn YN;Zimmer CT;Simon JC;Hayward A;Bass C
蚜虫Myzus persicae是一种破坏性的农业害虫，其表现出对天然和合成杀虫剂产生抗性的特殊能力。为了研究该物种中抗性的进化，我们产生了>110个完全测序的全局采样克隆系的染色体规模的基因组组装和活组。我们的分析揭示了一个显着的多样性耐药突变分离在全球人口的M。桃蚜。我们表明，这些机制的出现和传播受到寄主植物协会的影响，揭示了寄主植物适应的广泛选择，也提供了对合成杀虫剂的抗性。我们确定了在同一位点的独立抗性突变的重复进化，以及对关键杀虫剂的新抗性机制的进化的多个实例。我们的研究结果为全球昆虫种群对强选择力的基因组反应提供了基本见解，并对害虫和寄生虫的控制具有实际意义。Singh，Bass及其同事为蚜虫作物害虫Myzus persicae产生了新的基因组资源，包括染色体规模的基因组组装和>100个全球采样克隆系的重测序基因组。利用这个数据集，他们揭示了支持杀虫剂抗性进化的机制以及影响其出现和传播的生态因素。
The aphid Myzus persicae is a destructive agricultural pest that displays an exceptional ability to develop resistance to both natural and synthetic insecticides. To investigate the evolution of resistance in this species we generated a chromosome-scale genome assembly and living panel of >110 fully sequenced globally sampled clonal lines. Our analyses reveal a remarkable diversity of resistance mutations segregating in global populations of M. persicae. We show that the emergence and spread of these mechanisms is influenced by host–plant associations, uncovering the widespread co‐option of a host-plant adaptation that also offers resistance against synthetic insecticides. We identify both the repeated evolution of independent resistance mutations at the same locus, and multiple instances of the evolution of novel resistance mechanisms against key insecticides. Our findings provide fundamental insights into the genomic responses of global insect populations to strong selective forces, and hold practical relevance for the control of pests and parasites. Singh, Bass and colleagues generate new genomic resources for the aphid crop pest, Myzus persicae, comprising a chromosome-scale genome assembly and resequenced genomes of >100 globally sampled clonal lines. Using this dataset, they uncover both mechanisms underpinning the evolution of insecticide resistance and ecological factors that influence its emergence and spread.
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影响因子：
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作者：
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通讯作者：
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