Investigation of the influence of progesterone on mouse embryo transport by using antiprogestational steroids.
Investigation of the influence of progesterone on mouse embryo transport by using antiprogestational steroids.
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使用抗孕类固醇研究黄体酮对小鼠胚胎运输的影响。
DOI：
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发表时间：
1980
期刊：
影响因子：
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通讯作者：
B. Lee
中科院分区：
文献类型：
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作者：
K. Kendle;B. Lee
小鼠排卵后卵巢切除不改变胚胎通过输卵管的转运速度，排卵后给予黄体酮基本上不改变胚胎通过输卵管的速度，但在排卵前给予黄体酮可以增加胚胎通过输卵管的速度。在怀孕第1天、第2天或第3天服用抗孕激素RMI 12,936会导致胚胎运动停止，另一种黄体酮拮抗剂R2323也会导致胚胎运动延迟，尽管不是很明显。孕酮可逆转孕酮对小鼠卵子转运的影响，提示小鼠卵子转运过程是由孕酮触发的，需要持续的孕酮活动才能维持。
The rate of embryo transport through the mouse oviduct was unaltered by ovariectomy after ovulation, essentially unaltered by administration of progesterone after ovulation but increased by preovulatory administration of progesterone. The antiprogestational steroid RMI 12,936 caused an arrest of embryo movement when given on Day 1, 2 or 3 of pregnancy and similar, though less marked, delay was caused by R2323, another progesterone antagonist. The effects of RMI 12,936 given on Day 1 were reversed by progesterone administration after a latent period of 24-48 h. These results indicate that the egg transport process in the mouse in triggered by progesterone and requires continued progesterone activity for its maintenance.