Acoustic droplet vaporization and inertial cavitation thresholds and efficiencies of nanodroplets emulsions inside the focused region using a dual-frequency ring focused ultrasound.
Acoustic droplet vaporization and inertial cavitation thresholds and efficiencies of nanodroplets emulsions inside the focused region using a dual-frequency ring focused ultrasound.
复制标题
使用双频环形聚焦超声测量聚焦区域内纳米液滴乳剂的声学液滴蒸发和惯性空化阈值和效率。
DOI：
10.1016/j.ultsonch.2018.07.020
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发表时间：
2018-11
影响因子：
8.4
通讯作者：
Shanshan Xu;Nan Chang;Rui Wang;Xiaodong Liu;Shifang Guo;Supin Wang;Y. Zong;M. Wan
中科院分区：
文献类型：
--
作者：
Shanshan Xu;Nan Chang;Rui Wang;Xiaodong Liu;Shifang Guo;Supin Wang;Y. Zong;M. Wan
在这项工作中，为了开发一种低声强，高效率和精确的治疗策略，液滴的蒸发和蒸发微泡的惯性空化，使用双频聚焦超声换能器，进行了研究。低频（LF），1.1-MHz，超声对液滴蒸发和以下的惯性空化的影响，通过引入高频（HF），5-MHz，超声进行了研究。结果表明，在低频18.9W/cm 2和高频4.1W/cm 2的双频声处理条件下，声滴蒸发阈值最低，声滴蒸发效率最高。使用双频超声（LF为38.1 W/cm 2，HF为8.5 W/cm 2）可将ADV面积最小化至2 mm 2。IC面积和效率也可以使用双频超声处理来调制。因此，可以得出结论，与单频超声相比，使用双频超声，可以调制纳米液滴的蒸发和随后的蒸发微泡的惯性空化。此外，双频可以导致最小的ADV/IC面积、最低的ADV/IC阈值和最高的ADV/IC效率。
In this work, in order to develop a low-acoustic-intensity, high-efficiency and precise-treatment strategy, the vaporization of droplets and the inertial cavitation of vaporized microbubbles, using a dual-frequency focused ultrasound transducer, were investigated. The effect of a low frequency (LF), 1.1-MHz, sonication on droplet vaporization and the following inertial cavitation by the introduction of a high frequency (HF), 5-MHz, sonication was studied. It is shown that acoustic droplet vaporization (ADV) threshold is the lowest at dual-frequency sonication (LF of 18.9 W/cm2and HF of 4.1 W/cm2); moreover, the ADV efficiency is the highest at intensity threshold. The ADV area can be minimized to 2 mm2using a dual-frequency sonication (LF of 38.1 W/cm2and HF of 8.5 W/cm2). The IC area and efficiency can also be modulated using a dual-frequency sonication. Consequently, it can be concluded that in contrast to the single-frequency sonication, using the dual-frequency ultrasound, the vaporization of nanodroplets and the following inertial cavitation of the vaporized microbubbles can be modulated. Besides, a dual-frequency can result in the minimum ADV/IC area, lowest ADV/IC threshold, and highest ADV/IC efficiency.