Functional integration between the posterior hippocampus and prefrontal cortex is impaired in both first episode schizophrenia and the at risk mental state
Functional integration between the posterior hippocampus and prefrontal cortex is impaired in both first episode schizophrenia and the at risk mental state
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DOI：
10.1093/brain/awp098
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发表时间：
2009-09-01
期刊：
影响因子：
14.5
通讯作者：
McGuire, Philip
中科院分区：
文献类型：
--
作者：
Benetti, Stefania;Mechelli, Andrea;McGuire, Philip
最近的神经成像研究报告了精神分裂症患者前额叶皮质和海马结构之间的功能整合缺陷。目前尚不清楚这些变化是否是慢性病或其治疗的结果，也不清楚这些变化是否也明显存在于患病风险增加的非精神病受试者身上。我们通过研究首发精神分裂症患者和高危精神状态(ARMS)受试者的前额叶-海马区相互作用来解决这些问题。我们使用功能磁共振成像技术，测量了16名有手臂的个体、10名首发精神分裂症患者和14名健康对照在延迟匹配样本任务过程中的脑反应。使用动态因果模型估计前额叶皮质与海马区前部和后部之间的有效连接。无论是首发患者还是ARM患者，从右侧后海马到右额下回的正常有效连接模式均显著降低(ANOVA；F8.16，P0.01)。额叶下回和海马体前部之间的相互作用在三组中没有不同。在患精神病的高危人群和刚刚发展成精神分裂症的患者中，受扰的海马掌前额叶相互作用明显。这表明，这可能与精神病易感性增加有关，与慢性病或其治疗的影响无关。
Recent neuroimaging studies have reported deficits in functional integration between prefrontal cortex and the hippocampal formation in schizophrenia. It is unclear whether these alterations are a consequence of chronic illness or its treatment, and whether they are also evident in non-psychotic subjects at increased risk of the disorder. We addressed these issues by investigating prefrontalhippocampal interactions in patients with first episode schizophrenia and subjects with an At Risk Mental State (ARMS). Using functional Magnetic Resonance Imaging, we measured brain responses from 16 individuals with an ARMS, 10 patients with first episode schizophrenia and 14 healthy controls during a delayed matching to sample task. Dynamic causal modelling was used to estimate the effective connectivity between prefrontal cortex and anterior and posterior hippocampal regions. The normal pattern of effective connectivity from the right posterior hippocampus to the right inferior frontal gyrus was significantly decreased in both first episode patients and subjects with an ARMS (ANOVA; F 8.16, P 0.01). Interactions between the inferior frontal gyrus and the anterior part of the hippocampus did not differ across the three groups. Perturbed hippocampalprefrontal interactions are evident in individuals at high risk of developing psychosis and in patients who have just developed schizophrenia. This suggests that it may be a correlate of increased vulnerability to psychosis and that it is not attributable to an effect of chronic illness or its treatment.