Merkel cell development in the wound healing in the labial mucosa of adult rabbits.
Merkel cell development in the wound healing in the labial mucosa of adult rabbits.
复制标题
成年兔唇粘膜伤口愈合中默克尔细胞的发育。
DOI：
10.1679/aohc1950.44.151
复制
发表时间：
1981
期刊：
影响因子：
--
通讯作者：
K. Ishizeki
中科院分区：
文献类型：
--
作者：
T. Tachibana;K. Ishizeki
研究了梅克尔细胞在成年兔再生唇粘膜中的发育。取兔下唇粘膜全厚创面，于伤后2、7、10、14、21、30 d分别用电镜和光镜观察再生粘膜。7 d时，粘膜再生区被致密的板层结缔组织取代，板层结缔组织主要由胶原纤维层和成纤维细胞交替排列组成，其上覆有层状鳞状上皮。伤后7天未见默克尔细胞。损伤10天后，再生上皮中发现少量非常不成熟的默克尔细胞。在随后的再生过程中，默克尔细胞数量增加，结构成熟。损伤后30天，受伤区域愈合，没有形成疤痕组织，再生的上皮嵴通常包括常规型默克尔细胞。当实验中使用成年动物时，再生上皮中默克尔细胞的繁殖似乎独立于未分化的神经外胚层组织。
Merkel cell development was studied in the regenerative labial mucous membrane of adult rabbits. Fullthick wounds were made on the inferior labial mucous membrane of the rabbits, then the regenerative mucous membrane was examined by electron and light microscopy at time intervals of 2, 7, 10, 14, 21 and 30 days after the injury. By 7 days, the regenerative area of the mucous membrane was replaced with a dense lamellar connective tissue, which was mainly composed of alternately arranged collagen fiber layers and fibroblasts, and an overlying stratified squamous epithelium. No Merkel cell was found 7 days after the injury. Ten days after the injury, a few very immature Merkel cells were identified in the regenerative epithelium. The Merkel cells increased in number and matured in structure during the course of the following regenerative period. Thirty days after the injury, the wounded area healed without forming a scar tissue, and the regenerated epithelial ridges usually included regular type Merkel cells. As adult animals were used in this experiment, the reproduction of the Merkel cell in the regenerative epithelium seemed to be independent of the undifferentiated neuroectodermal tissue.