Overexpression of EPHB4 Is Associated with Poor Survival of Patients with Gastric Cancer
Overexpression of EPHB4 Is Associated with Poor Survival of Patients with Gastric Cancer
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DOI：
10.21873/anticanres.11845
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发表时间：
2017-08-01
影响因子：
2
通讯作者：
Jiang, Wen G.
中科院分区：
文献类型：
--
作者：
Yin, Jie;Cui, Yuxin;Jiang, Wen G.
Background: Increased expression of erythropoietin-producing human hepatoma (EPHB4) leads to enhanced cell migration, growth and adhesion in tumor cells. However, little is known regarding the effects of EPHB4 in gastric cancer. The present study aimed to examine the clinical relevance of EPHB4 and its association with the prognosis of gastric cancer. Materials and Methods: EPHB4 transcript expression in 324 gastric cancer samples with paired adjacent normal gastric tissues was determined using quantitative polymerase chain reaction and the results were statistically analyzed against patient clinicopathological data. AGS and HGC27 cell lines were transfected with EPHB4 siRNA and the effects examined by functional analysis. Results: EPHB4 mRNA levels in gastric cancer tissues were significantly elevated when compared to non-cancerous tissues (p=0.0110). Tissue samples from male patients exhibited lower expression than those from female patients (p=0.0110). Non-cardiac gastric tumors (fundus, corpus and pylorus) expressed a higher number of EPHB4 transcripts in comparison to cardiac gastric tumors (p
