Metabolic syndrome in childhood predicts adult cardiovascular disease 25 years later: The Princeton Lipid Research Clinics follow-up study
Metabolic syndrome in childhood predicts adult cardiovascular disease 25 years later: The Princeton Lipid Research Clinics follow-up study
复制标题
DOI：
10.1542/peds.2006-1699
复制
发表时间：
2007-08-01
期刊：
影响因子：
8
通讯作者：
Gray-McGuire, Courtney
中科院分区：
文献类型：
--
作者：
Morrison, John A.;Friedman, Lisa Aronson;Gray-McGuire, Courtney
目标。该研究的目标是评估儿童时期代谢综合征与25年后成人心血管疾病的相关性。数据来自国家心脏、肺和血液研究所血脂研究诊所普林斯顿流行研究(1973-1976)和普林斯顿随访研究(2000-2004)。BMI在儿童时期被用作肥胖的衡量标准，因为在脂肪研究诊所的研究中没有测量腰围。通过参与者报告获得参与者及其父母的成人心血管疾病状况。Logistic分析用于预测成人心血管疾病；儿童代谢综合征、在普林斯顿大学进行随访研究的年龄、性别、种族和父母心血管疾病病史是潜在的解释变量。在血脂研究临床研究中，年龄从6岁到19岁不等，在普林斯顿大学的随访研究中，年龄从30岁到48岁不等。在普林斯顿的后续研究中，分析队列中有17例心血管疾病。儿科代谢综合征和随访评估时的年龄是心血管疾病的重要预测因素。儿童代谢综合征和从儿童到成年的特定年龄BMI百分位数的变化是成人代谢综合征的重要预测因素。评估儿童的代谢综合征可以发现成人心血管疾病风险增加的患者，使有针对性的干预成为可能。
Objective. The goal was to assess the association of metabolic syndrome in childhood with adult cardiovascular disease 25 years later.Methods. Data from the National Heart, Lung, and Blood Institute Lipid Research Clinics Princeton Prevalence Study (1973-1976) and the Princeton Follow-up Study (2000-2004) were used. BMI was used as the obesity measure in childhood, because waist circumference was not measured in the Lipid Research Clinics study. The adult cardiovascular disease status of participants and their parents was obtained through participant report. A logistic analysis was used to predict adult cardiovascular disease; pediatric metabolic syndrome, age at the Princeton Followup Study, gender, race, and parental history of cardiovascular disease were potential explanatory variables.Results. Ages ranged from 6 to 19 years in the Lipid Research Clinics study and from 30 to 48 years in the Princeton Follow-up Study. There were 17 cases of cardiovascular disease in the analysis cohort in the Princeton Follow-up Study. Pediatric metabolic syndrome and age at follow-up assessment were significant predictors of cardiovascular disease. Pediatric metabolic syndrome and changes in age-specific BMI percentile from childhood to adulthood were significant predictors of adult metabolic syndrome.Conclusions. Evaluating children for metabolic syndrome could identify patients at increased risk of adult cardiovascular disease, making targeted interventions possible.