Correlation between late gadolinium enhancement and diastolic function in hypertrophic cardiomyopathy assessed by magnetic resonance imaging
Correlation between late gadolinium enhancement and diastolic function in hypertrophic cardiomyopathy assessed by magnetic resonance imaging
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DOI：
10.1253/circj.72.378
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发表时间：
2008-03-01
影响因子：
3.3
通讯作者：
Sakuma, Hajime
中科院分区：
文献类型：
--
作者：
Motoyasu, Munenobu;Kurita, Tairo;Sakuma, Hajime
背景：肥厚型心肌病(HCM)患者普遍存在舒张期功能障碍。稳态电影磁共振成像(MRI)可以测量左心室(LV)的舒张期功能，晚期Gd增强MRI可以描绘肥厚性心肌病纤维化的存在和程度。方法和结果17例肥厚型心肌病患者，男13例，平均年龄57.7±9.8岁。通过对30个心肌节段组织强化程度的评分，确定晚期Gd强化的严重程度指数。用电影MRI测定峰值充盈率(PFR)、左心室射血分数和左心室重量。增强MRI显示510个节段中有97个节段(19%)和17个患者中的13个节段(77%)出现晚期Gd强化。晚期Gd强化严重程度指数与PFR呈显著负相关(r=-0.86，P
Background Diastolic dysfunction is common in patients with overt hypertrophic cardiomyopathy (HCM). Steady-state cine magnetic resonance imaging (MRI) enables measurement of the diastolic function of the left ventricle (LV), and late gadolinium enhanced MRI can delineate the presence and extent of fibrosis in HCM. The purpose of this study was to determine the relationship between the extent of myocardial fibrosis demonstrated by late gadolinium-enhanced MRI and diastolic dysfunction.Methods and Results Seventeen patients (13 men, mean age 57.7 +/- 9.8 years) with HCM were studied. The severity index of late gadolinium enhancement was determined by scoring the extent of enhanced tissue in 30 myocardial segments. The peak filling rate (PFR), LV ejection fraction and LV mass were determined by cine MRI. Contrast-enhanced MRI demonstrated late gadolinium enhancement in 97 of 510 segments (19%) and 13 of the 17 patients (77%). The severity index of late gadolinium enhancement demonstrated a significant negative correlation with PFR (r=-0.86, p