Isocapnic hyperpnoea accelerates recovery from isoflurane anaesthesia
Isocapnic hyperpnoea accelerates recovery from isoflurane anaesthesia
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DOI：
10.1093/bja/aeg269
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发表时间：
2003-12-01
影响因子：
9.8
通讯作者：
Sasano, H
中科院分区：
文献类型：
--
作者：
Vesely, A;Fisher, JA;Sasano, H
背景过度换气应加速挥发性麻醉剂从体内的消除，但过度换气通常导致低碳酸血症。我们比较了异氟醚麻醉后辅助自主通气（对照组）和等二氧化碳高通气治疗患者的恢复情况。14例患者在用异氟烷麻醉约1小时后进行了研究。对照组患者以常规方式恢复。等碳酸血症患者接受2-3次术中通气，使用系统将潮气末PCO 2维持在45-50 mm Hg。观察两组患者恢复期拔出气道的时间和脑电双频指数（BIS）的变化。在等二氧化碳高呼吸状态下，移除气道的时间明显更短（中位数和四分位距值分别为3.6（2.7-3.7）和12.1（6.8-17.2）min，P
Background. Hyperventilation should speed up elimination of volatile anaesthetic agents from the body, but hyperventilation usually results in hypocapnia. We compared recovery from isoflurane anaesthesia in patients allowed to recover with assisted spontaneous ventilation (control) and those treated with isocapnic hyperpnoea.Methods. Fourteen patients were studied after approximately I h of anaesthesia with isoflurane. Control patients were allowed to recover in the routine way. Isocapnic hyperpnoea patients received 2-3 times their intraoperative ventilation using a system to maintain end tidal PCO2 at 45-50 mm Hg. We measured time to removal of the airway and rate of change of bispectral index (BIS) during recovery.Results. With isocapnic hyperpnoea, the time to removal of the airway was markedly less (median and interquartile range values of 3.6 (2.7-3.7) vs 12.1 (6.8-17.2) min, P