Process Control of Electrospinning Artificial Fenestrated Capillary Vessels
Process Control of Electrospinning Artificial Fenestrated Capillary Vessels
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DOI：
10.1016/j.matdes.2023.111708
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发表时间：
2023-02
期刊：
影响因子：
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通讯作者：
Imtiaz Qavi;George Z. Tan
中科院分区：
文献类型：
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作者：
Imtiaz Qavi;George Z. Tan
快速制造毛细血管对于组织工程非常重要，因为组织内的局部灌注和氧交换依赖于直径从5到10微米的毛细血管网络。有孔毛细血管是一种微血管，其表面有直径为80至100纳米的孔。这些毛细血管对许多器官都是必不可少的，比如小肠、内分泌腺和肾脏。本文提出了一种以聚己内酯和聚氧化物为原料的湿式同轴静电纺丝技术，用于快速制备多孔微管作为人工开孔毛细血管。我们通过回归模型表征了工艺参数对这些微管形态特征的影响。我们的研究表明，岩心/护套溶液的流速比和护套溶液的粘度对微管的外径、壁厚和空心面积有显著影响。此外，静电纺丝过程中表面孔隙的形成主要受湿度的影响。在相同湿度水平下，表面孔隙的大小与鞘液粘度和微管外径呈正相关。总的来说，本研究建立了人工开孔毛细血管湿式同轴静电纺丝的工艺-性能关系。
Rapid fabrication of capillary vessels is important for tissue engineering because local perfusion and oxygen exchange within the tissue depend on the network of capillaries which have diameters ranging from 5 to 10 µm. Fenestrated capillaries are microvessels that have surface pores of 80 to 100 nm in diameter. These capillaries are essential for many organs, such as small intestines, endocrine glands, and kidneys. In this paper, we presented a wet coaxial electrospinning technique for the rapid fabrication of porous microtubes as artificial fenestrated capillaries using polycaprolactone and polyethylene oxide. We characterized the effects of process parameters on the morphological features of these microtubes by regression modeling. Our study shows that the flow rate ratio of the core/sheath solutions and the viscosity of the sheath solution play a significant role in the outside diameter, wall thickness, and hollow area of the microtubes. In addition, the formation of surface pores is dominated by the humidity during the electrospinning. At the same humidity level, the size of the surface pores is positively correlated with the viscosity of the sheath solution and the outside diameter of the microtubes. Overall, this study established the process-property relationship for wet coaxial electrospinning of artificial fenestrated capillaries.