A limited survey-based uncontrolled follow-up study of children born after ooplasmic transplantation in a single centre
A limited survey-based uncontrolled follow-up study of children born after ooplasmic transplantation in a single centre
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DOI：
10.1016/j.rbmo.2016.10.003
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发表时间：
2016-12-01
影响因子：
4
通讯作者：
Cohen, Jacques
中科院分区：
文献类型：
--
作者：
Chen, Serena H.;Pascale, Claudia;Cohen, Jacques
1996 年至 2001 年间，美国圣巴拿巴医学中心进行了从供体卵母细胞到受体卵母细胞的实验性卵质移植。 33 名患者的适应症是反复植入失败。十三对夫妇生育了 17 个孩子。一名患者从混合卵质胚胎和供体卵胚胎中产下双胞胎。据报道，一项针对儿童的有限的基于调查的跟踪研究显示：13 名家长中有 12 名填写了有关怀孕、出生、健康、学业表现和披露的调查问卷。四胞胎的父母没有参加。产前发育和分娩都很顺利。学校成绩从良好到优秀。孩子们身体健康。 13 名儿童中有 12 名体重指数 (BMI) 正常。一名儿童患有慢性偏头痛，两名儿童患有轻度哮喘，三名儿童患有轻微视力问题，三名儿童患有轻微皮肤问题。男孩/女孩双胞胎中的一名男孩在 18 个月大时被诊断出患有边缘性广泛性发育障碍（未另行明确），但后来没有任何症状。一对夫妇向他们的孩子透露了卵子捐赠者的使用情况。一项报告意向披露；六家尚未做出决定，四家表示不愿透露。这种有限的后续策略存在很高的偏差风险。由于缺乏向孩子披露信息，家长可能不同意标准化临床分析。 (C) 2016 年作者。由 Elsevier Ltd 代表 Reproductive Healthcare Ltd 发布。
Experimental ooplasmic transplantation from donor to recipient oocyte took place between 1996 and 2001 at Saint Barnabas Medical Center, USA. Indication for 33 patients was repeated implantation failure. Thirteen couples had 17 babies. One patient delivered twins from mixed ooplasmic and donor egg embryos. A limited survey-based follow-up study on the children is reported: 12 out of 13 parents completed a questionnaire on pregnancy, birth, health, academic performance and disclosure. Parents of a quadruplet did not participate. Prenatal development and delivery were uneventful. School grades ranged from good to excellent. Children were of good health. Body mass index (BMI) was normal in 12 out of 13 children. One child had chronic migraine headaches, two mild asthma, three minor vision and three minor skin problems. One boy from a boy/girl twin was diagnosed with borderline pervasive developmental disorder - not otherwise specified at age 18 months, but with no later symptoms. One couple disclosed the use of egg donor to their child. One reported intention to disclose; six were undecided and four reported they would not disclose. This limited follow-up strategy presents a high risk of bias. Parents may not assent to standardized clinical analysis owing to lack of disclosure to their children. (C) 2016 The Authors. Published by Elsevier Ltd on behalf of Reproductive Healthcare Ltd.