Cognitive slowing in multiple sclerosis is strongly associated with brain volume reduction
Cognitive slowing in multiple sclerosis is strongly associated with brain volume reduction
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多发性硬化症的认知减慢与脑容量减少密切相关
DOI：
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发表时间：
2006
期刊：
影响因子：
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通讯作者：
F. Barkhof
中科院分区：
文献类型：
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作者：
R. Lazeron;Leo M. J. Sonneville;P. Scheltens;C. Polman;F. Barkhof
在这项研究中，我们研究了体内疾病病理(以磁共振成像(MRI)病变负荷和脑体积缩小来衡量)对多发性硬化症(MS)患者认知功能，特别是处理速度的影响。由于多发性硬化症的特点是认知减慢而不是准确性受损，我们使用了阿姆斯特丹神经心理任务(ANT)程序，这是一种被证明对多发性硬化症患者的认知减慢非常敏感的计算机化测试。方法对32例患者行经皮冠状动脉腔内成形术并行MRI扫描。使用ANT计算机化测试，我们调查了集中、分散、持续注意、执行功能和精神运动功能，并检验了这些测试的速度、速度波动和准确性与MRI病变负荷和脑体积参数的关系。结果加工速度和反应速度稳定性降低，精神运动准确性和稳定性降低明显与脑体积减少和损伤负荷增加有关，尤其是额区和枕区。除视觉空间处理外，所有领域都与脑体积缩小相关。特别是，速度和速度波动分数与大脑体积减少相关，而总体来说，表现的准确性并不相关。只有部分测试速度分数和速度波动分数与病变负荷测量相关。结论本研究表明，在多发性硬化症患者中，除非涉及高工作记忆需求，否则处理的准确性不会受到影响。多发性硬化症患者的神经认知功能问题主要受速度处理的速度和稳定性的调节，特别是当需要注意力要求的受控信息处理时。这些区域的异常与脑体积损失最相关，证实了局灶性病变以外的病理在MS中是重要的。
Introduction In this study, we investigated the influence of in vivo disease pathology (measured as magnetic resonance imaging (MRI) lesion load and brain volume reduction) on cognitive functioning, especially the speed of processing, in multiple sclerosis (MS) patients. Since MS is characterized by cognitive slowing rather than impaired accuracy, we used the Amsterdam Neuropsychological Tasks (ANT) program, a computerized test proven to be very sensitive to cognitive slowing in MS patients. Methods Thirty-two patients performed the ANT and underwent MRI scanning. Using the ANT computerized tests, we investigated focused, divided, sustained attention, executive function and psychomotor function, and examined associations of speed, speed fluctuation and accuracy of performance of these tests with MRI lesion load and brain volume parameters. Results A decrease in the speed of processing and response speed stability, and a decrease in psychomotor accuracy and stability were clearly associated with less brain volume, and with higher lesion loads, in particular at frontal and occipital areas. Correlations with brain volume reduction were found for all domains, except for visuo-spatial processing. In particular, speed and speed fluctuation scores correlated with brain volume reduction, while accuracy of performance, in general, did not correlate. Only some test speed scores and speed fluctuation scores correlated with lesion load measurements. Conclusion This study shows that, in MS patients, accuracy of processing is not compromised unless high working memory demands are involved. Problems in neurocognitive functioning in MS are mainly modulated by speed and stability of speed processing, in particular when attention-demanding controlled information processing is required. Abnormalities in these domains are most strongly associated with brain volume loss, confirming that pathology beyond focal lesions is important in MS.
多发性硬化症患者的信息处理速度。
影响因子：
2.2
作者：
Rao,SM;StAubin-Faubert,P;Leo,GJ
通讯作者：
Leo,GJ