Advancing critical care medicine with stem cell therapy and hypothermia for cerebral palsy.
Advancing critical care medicine with stem cell therapy and hypothermia for cerebral palsy.
复制标题
通过干细胞疗法和脑瘫的体温过低来推进重症监护医学。
DOI：
10.1097/wnr.0000000000000062
复制
发表时间：
2013-12-18
期刊：
影响因子：
1.7
通讯作者：
Borlongan CV
中科院分区：
文献类型：
--
作者：
Dailey T;Mosley Y;Pabon M;Acosta S;Tajiri N;van Loveren H;Kaneko Y;Borlongan CV
With limited clinical trials in stem cell therapy for adult stroke underway, the assessment of efficacy also needs to be considered for neonatal hypoxic-ischemic brain injury, considering its distinct symptoms. The critical nature of this condition establishes deficits that last a lifetime. Here, we will highlight the progress of current translational research, commenting on the critical nature of the disease, stem cell sources, the use of hypothermia, safety and efficacy of each treatment, modes of action, and the possibility of combination therapy. With this in mind, we reference translational guidelines established by a consortium of research partners called Stem cell Therapeutics as an Emerging Paradigm for Stroke (STEPS). The guidelines of STEPS are directed for evaluating outcomes for cell therapy in adult stroke; however, we identify the overlapping pathology, as we believe these guidelines will serve well in the investigation of neonatal hypoxic-ischemic therapy. Lastly, discussion into current treatment and a case report demonstrate that the capabilities for these treatments have arrived and the time for advancing stem cell therapy and hypothermia for cerebral palsy is now.
