Remission to normoalbuminuria during multifactorial treatment preserves kidney function in patients with type 2 diabetes and microalbuminuria
Remission to normoalbuminuria during multifactorial treatment preserves kidney function in patients with type 2 diabetes and microalbuminuria
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DOI：
10.1093/ndt/gfh470
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发表时间：
2004-11-01
影响因子：
6.1
通讯作者：
Pedersen, O
中科院分区：
文献类型：
--
作者：
Gæde, P;Tarnow, L;Pedersen, O
背景。对微量白蛋白尿2型糖尿病患者的干预研究表明，有可能避免进展为显性糖尿病肾病，甚至可以恢复到正常的白蛋白尿。然而，蛋白尿的稳定/消退对肾小球滤过率（GFR）下降的长期影响尚未确定。在7.8年的随访中，151例2型糖尿病合并微量白蛋白尿患者基线GFR测量至少3次，根据随访期间的白蛋白尿水平分为三组。公开性肾病诊断为尿白蛋白排泄率（AER） bb0 300mg/24h，缓解至尿白蛋白正常为AER
Background. Intervention studies in microalbuminuric type 2 diabetic patients have demonstrated that it is possible to avoid progression to overt diabetic nephropathy and even to achieve regression to normoalbuminuria. However, the long-term impact of stabilization/regression in albuminuria on decline in glomerular filtration rate (GFR) has not been established.Methods. 151 patients with type 2 diabetes and microalbuminuria at baseline in whom GFR was measured at least three times during 7.8 years of follow-up were divided into three groups according to the level of albuminuria during follow-up. Overt nephropathy was diagnosed as a urinary albumin excretion rate (AER) >300mg/24h and remission to normoalbuminuria was defined as an AER