An occupation and exposure linkage system for the study of occupational carcinogenesis.
An occupation and exposure linkage system for the study of occupational carcinogenesis.
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用于研究职业致癌的职业和暴露联动系统。
DOI：
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发表时间：
1980
期刊：
影响因子：
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通讯作者：
D. Silverman
中科院分区：
文献类型：
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作者：
S. Hoar;A. S. Morrison;P. Cole;D. Silverman
当工作可以根据所涉及的特定化学或物理因素进行分类时，对职业接触的不利影响的研究最能提供信息。然而，通常无法获得足够详细的信息来实现这一点。在这种情况下，研究通常将基于根据行业或任务分类的主题，有效地忽略发生接触的特定物质。这种粗略的分类往往会减少或模糊特定暴露与疾病之间的关联。针对这个问题，作者开发了一个职业和暴露联系系统，特别提到致癌作用。职业按行业和行业内的任务进行分类。制定了可疑致癌物清单，每种可疑致癌物都与其使用的行业和任务相关。这些链接使得将其工作经历表明与特定特工有过接触的所有研究对象置于同一暴露类别中成为可能。流行病学分析可以基于化学和物理暴露，而不是基于行业或任务。该链接系统提高了从死亡证明、癌症登记、医疗记录和调查问卷中获得的职业信息的价值。
Studies of the adverse effects of occupational exposures are most informative when jobs can be classified according to the specific chemical or physical agents involved. However, information sufficiently detailed to permit this is not often available. In such instances a study usually will be based on subjects classified according to industry or task, effectively ignoring the specific agents to which exposure occurred. Such crude classification tends to reduce or obscure associations between specific exposures and disease. In response to this problem, the authors have developed an occupation and exposure linkage system with particular reference to carcinogenesis. Occupations were classified by industry and by task within the industry. Lists of suspect carcinogens were developed and each suspect carcinogen was linked to industries and tasks in which it has been used. These links make it possible to place in the same exposure category all study subjects whose employment history suggests contact with a particular agent. Epidemiologic analysis then can be based on chemical and physical exposures, rather than on industries or tasks. The linkage system enhances the value of information on occupation obtained from death certificates, cancer registries, medical records, and questionnaires.