Physiological and pathological role of alpha-synuclein in Parkinson's disease through iron mediated oxidative stress; the role of a putative iron-responsive element.
Physiological and pathological role of alpha-synuclein in Parkinson's disease through iron mediated oxidative stress; the role of a putative iron-responsive element.
复制标题
DOI：
10.3390/ijms10031226
复制
发表时间：
2009-03
影响因子：
5.6
通讯作者：
Rogers JT
中科院分区：
文献类型：
--
作者：
Olivares D;Huang X;Branden L;Greig NH;Rogers JT
帕金森病（PD）是仅次于阿尔茨海默病（AD）的第二种最常见的进行性神经退行性疾病，并且对社会造成巨大的健康负担。遗传和氧化风险因素已被认为是可能的原因，但它们的相对贡献仍不清楚。α-突触核蛋白（α-syn）的功能障碍与PD相关，因为它与铁一起在路易体中增加。铁引起的脑氧化损伤可能部分由PD病理过程中的α-syn寡聚化介导。此外，α-syn基因剂量可引起家族性PD，并且通过其5 '-非翻译区中新鉴定的铁响应元件样RNA序列阻断翻译来抑制其基因表达可提供新的PD药物靶点。
Parkinson’s disease (PD) is the second most common progressive neurodegenerative disorder after Alzheimer’s disease (AD) and represents a large health burden to society. Genetic and oxidative risk factors have been proposed as possible causes, but their relative contribution remains unclear. Dysfunction of alpha-synuclein (α-syn) has been associated with PD due to its increased presence, together with iron, in Lewy bodies. Brain oxidative damage caused by iron may be partly mediated by α-syn oligomerization during PD pathology. Also, α-syn gene dosage can cause familial PD and inhibition of its gene expression by blocking translation via a newly identified Iron Responsive Element-like RNA sequence in its 5’-untranslated region may provide a new PD drug target.
登录
查看更多内容
DOI：
10.1083/jcb.138.3.495
发表时间：
1997-08-11
期刊：
The Journal of cell biology
影响因子：
--
作者：
Chen YG;Siddhanta A;Austin CD;Hammond SM;Sung TC;Frohman MA;Morris AJ;Shields D
通讯作者：
Shields D
影响因子：
3.3
作者：
Carvey, PM;Pieri, S;Ling, ZD
通讯作者：
Ling, ZD
影响因子：
2.9
作者：
Cohlberg, JA;Li, J;Fink, AL
通讯作者：
Fink, AL
影响因子：
2.9
作者：
Conway, KA;Harper, JD;Lansbury, PT
通讯作者：
Lansbury, PT
影响因子：
6
作者：
Borie, C;Gasparini, F;Grandchamp, B
通讯作者：
Grandchamp, B