Blood manganese content at birth and cord serum prolactin levels
Blood manganese content at birth and cord serum prolactin levels
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DOI：
10.1016/j.ntt.2004.07.001
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发表时间：
2004-11-01
影响因子：
2.9
通讯作者：
Lafond, J
中科院分区：
文献类型：
--
作者：
Takser, L;Mergler, D;Lafond, J
锰（Mn）既是一种必需元素，在高剂量下，也是一种可以与多巴胺能神经传递相互作用的强效神经毒素。血浆催乳素（PRL），多巴胺能功能的间接指标，已被证明是不同的锰暴露在成人中，但很少有人知道这种关系在发育中的大脑。本研究的目的是探讨母亲和脐带血锰浓度在出生时和PRL脐带血水平之间的关系。本文测定了87例孕妇分娩时的血锰水平，并测定了脐血血浆中的催乳素。脐带血锰浓度（平均34.4 μ g/l，范围16.7-89.4）与脐带PRL水平显著正相关。这些研究结果表明，在子宫内锰积累可能有助于PRL水平的变化，在新生儿，这反过来又可能影响重要的发育参数。(C)2004年爱思唯尔公司All rights reserved.
Manganese (Mn) is both an essential element and, at a high dose, a potent neurotoxin that can interact with dopaminergic neurotransmission. Plasma prolactin (PRL), an indirect indicator of dopaminergic functioning, has been shown to vary with Mn exposure in adults, but little is known about this relation in the developing brain. The objective of this study was to examine the relations between maternal and cord Mn blood concentrations at birth and PRL cord blood levels. Blood Mn levels were determined in 87 pregnant women at delivery, and PRL was measured in the cord blood plasma. Mn cord blood concentration (mean 34.4 mug/l, range 16.7-89.4) was significantly and positively related to cord PRL levels. These findings suggest that Mn accumulation in utero could contribute to PRL level variation in neonates, which, in turn, may influence important developmental parameters. (C) 2004 Elsevier Inc. All rights reserved.