Determination of relative binding affinities of labeling molecules with amino acids by using scanning tunneling microscopy
Determination of relative binding affinities of labeling molecules with amino acids by using scanning tunneling microscopy
复制标题
使用扫描隧道显微镜测定标记分子与氨基酸的相对结合亲和力
DOI：
10.1039/c1cc12380g
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发表时间：
2011-01-01
影响因子：
4.9
通讯作者：
Wang, Chen
中科院分区：
文献类型：
--
作者：
Wang, Chenxuan;Mao, Xiaobo;Wang, Chen
用扫描隧道显微镜（STM）研究了标记分子酞菁铜四磺酸钠（PcCu（SO3Na）（4））在典型聚氨基酸组装体上的结合行为。通过在STM图像中直接观察标记物质在肽组装体上的吸附和分布，可以获得标记分子与不同氨基酸残基的相对结合亲和力。
The binding behaviour of labeling molecule copper phthalocyanine tetrasulfonate sodium (PcCu(SO3Na)(4)) on the assemblies of representative polyamino acids has been studied by using scanning tunneling microscopy (STM). By directly visualizing the adsorption and distribution of the labeling species on the peptide assemblies in STM images, one could obtain relative binding affinities of the labeling molecule with different amino acid residues.