Modes of remodeling in the cortical cytoskeleton of vascular endothelial cells.
Modes of remodeling in the cortical cytoskeleton of vascular endothelial cells.
复制标题
血管内皮细胞皮质细胞骨架的重塑模式。
DOI：
10.1016/j.febslet.2004.12.014
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发表时间：
2005
期刊：
影响因子：
--
通讯作者：
Hoh,JanH
中科院分区：
文献类型：
--
作者：
Pesen,Devrim;Hoh,JanH
血管内皮细胞的皮层细胞骨架在响应机械刺激和控制细胞表面蛋白分布方面起着重要作用。在这里，我们已经使用原子力显微镜可视化的动态皮质细胞骨架在活牛肺动脉内皮细胞。我们证明，皮质细胞骨架，组织为一个复杂的多边形网格，是高度动态的，并显示两种模式的重塑：完整的边界模式，网格单元边界保持完整，但移动在0.08μm/min允许网格单元改变形状，和改变边界模式，新的网格边界形成和现有的消失。
The cortical cytoskeleton of vascular endothelial cells plays an important role in responding to mechanical stimuli and controlling the distribution of cell surface proteins. Here, we have used atomic force microscopy to visualize the dynamics of cortical cytoskeleton in living bovine pulmonary artery endothelial cells. We demonstrate that the cortical cytoskeleton, organized as a complex polygonal mesh, is highly dynamic and shows two modes of remodeling: intact-boundary-mode where mesh element boundaries remain intact but move at ∼0.08μm/min allowing the mesh element to change shape, and altered-boundary-mode where new mesh boundaries form and existing ones disappear.