Epithelial Stem Cells
Epithelial Stem Cells
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DOI：
10.1007/978-1-61779-145-1_18
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发表时间：
2011-01-01
期刊：
影响因子：
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通讯作者：
Lyle, Stephen
中科院分区：
文献类型：
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作者：
Draheim, Kyle M.;Lyle, Stephen
成人上皮干细胞很可能可用于治疗外胚发育不良、念珠状发、内瑟顿综合征、门克斯病、遗传性大疱性表皮松解症和脱发等疾病。此外，其他皮肤问题，如烧伤，慢性伤口和溃疡将受益于干细胞相关疗法。然而，在实现这一目标之前，还有许多问题需要回答。这些问题中最重要的是什么调节干细胞粘附到小生境，而不是迁移到损伤部位。我们已经开始确定参与这一决策过程的机制。
It is likely that adult epithelial stem cells will be useful in the treatment of diseases, such as ectodermal dysplasias, monilethrix, Netherton syndrome, Menkes disease, hereditary epidermolysis bullosa, and alopecias. Additionally, other skin problems such as burn wounds, chronic wounds, and ulcers will benefit from stem cell-related therapies. However, there are many questions that need to be answered before this goal can be realized. The most important of these questions is what regulates the adhesion of stem cells to the niche versus migration to the site of injury. We have started to identify the mechanisms involved in this decision-making process.