Gilman-Type versus Lipshutz-Type Reagents: Competition in Lithiocuprate Chemistry
Gilman-Type versus Lipshutz-Type Reagents: Competition in Lithiocuprate Chemistry
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DOI：
10.1021/om801101u
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发表时间：
2009-01-12
期刊：
影响因子：
2.8
通讯作者：
Raithby, Paul R.
中科院分区：
文献类型：
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作者：
Haywood, Joanna;Morey, James V.;Raithby, Paul R.
CuCN与RLi和TMPLi（TMP = 2，2，6，6-四甲基哌啶）反应，得到Gilman型铜酸盐R（TMP）CuLi·nL（R = Ph，n = 3，L = THF 2; R = Me，n = 1，L = TMEDA 3）. 3和3.LiCN已经在定向邻位铜化中进行了测试，数据表明Lipshutz型3.LiCN的效率提高; Lipshutz型和Gilman型制剂之间的竞争通过DFT方法合理化。
CuCN reacts with RLi and TMPLi (TMP = 2,2.6,6-tetramethylpiperidide) to give Gilman-type cuprates R(TMP)CuLi.nL (R = Ph, n = 3, L = THF 2; R = Me, n = 1, L = TMEDA 3). 3 and 3.LiCN have been tested in directed ortho cupration with data suggesting enhanced efficiency for Lipshutz-type 3.LiCN; competition between Lipshutz- and Gilman-type formulations is rationalized by DFT methods.